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3.5.2.B2: (+)-gamma-lactamase

This is an abbreviated version!
For detailed information about (+)-gamma-lactamase, go to the full flat file.

Word Map on EC 3.5.2.B2

Reaction

a (+)-gamma-lactam
+
H2O
=
a substituted gamma-amino acid

Synonyms

(+) gamma-lactamase, (+)-gamma-lactamase, BJ6T_02120, Daci_0225, Delm, FDB1, FGSG_00079, FPSE_08124, IHL, isochorismatase-like hydrolase, Mh33H4-5540, MhIHL, Mhpg, RutB, Sslact, SSO2810, Sspg, SYJ322B5

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.B2 (+)-gamma-lactamase

Crystallization

Crystallization on EC 3.5.2.B2 - (+)-gamma-lactamase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
molecular modeling. Structure does not show similartity to the domain structure of known gamma-lactamases, leading to gamma lactamase type II
-
homology modeling and molecular docking. The active site is located in the middle of the core structure, the catalytic triad is constituted by residues S171, S195, C145
-
purified apo-form, (+)-gamma-lactam bound, and (-)-gamma-lactam bound forms of the enzyme, X-ray diffraction structure determination and analysis at 1.79-2.05 A resolution
sitting drop vapor diffusion method at 20°C, crystal structures of the apo-form, (+)-gamma-lactam bound, and (-)-gamma-lactam bound forms of the enzyme