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3.5.2.9: 5-oxoprolinase (ATP-hydrolysing)

This is an abbreviated version!
For detailed information about 5-oxoprolinase (ATP-hydrolysing), go to the full flat file.

Word Map on EC 3.5.2.9

Reaction

ATP
+
5-oxo-L-proline
 + 2 H2O =
ADP
 +
phosphate
 +
L-glutamate

Synonyms

5-OPase, 5-oxo-L-prolinase, 5-oxoprolinase, 5OPase, ATP-dependent 5-oxoprolinase, FgOXP1, FgOXP2, FGSG_04902, FGSG_10203, L-pyroglutamate hydrolase, OPase, oplA, OPLAH, oxoprolinase, OXP1, PA4511, prokaryotic 5-oxoprolinase, PxpA, pxpA3, pxpB, pxpC, pyroglutamase, pyroglutamase (ATP-hydrolysing), pyroglutamate hydrolase, pyroglutamic hydrolase, SSO1667

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.9 5-oxoprolinase (ATP-hydrolysing)

Specific Activity

Specific Activity on EC 3.5.2.9 - 5-oxoprolinase (ATP-hydrolysing)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00195
cytosolic fraction of kidney
0.625
after purification by Sepharyl S-300, Blue Sepharose and Phenyl Sepharose column chromatography
1
-
measured in tumor tissue after treatment with dietary glutamine
1.25
-
measured in jejunal mucosa in DMBA-teated rats with tumor
2.5
-
measured in tumor tissue
2.91
-
measured in jejunal mucosa in DMBA-treated rats without tumor
3
-
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats without tumor
3.6
-
-
3.75
-
measured in jejunal mucosa in normal rats
4.17
-
measured in jejunal mucosa after treatment with dietary glutamine in normal rats
4.33
-
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats with tumor