3.5.2.9: 5-oxoprolinase (ATP-hydrolysing)
This is an abbreviated version!
For detailed information about 5-oxoprolinase (ATP-hydrolysing), go to the full flat file.
Word Map on EC 3.5.2.9
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3.5.2.9
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5-oxoproline
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gamma-glutamyl
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5-oxoprolinuria
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l-2-oxothiazolidine-4-carboxylate
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medicine
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cyclotransferase
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decyclization
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gamma-glutamyl-cysteine
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atp-hydrolyzing
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meister
- 3.5.2.9
- 5-oxoproline
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gamma-glutamyl
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5-oxoprolinuria
- l-2-oxothiazolidine-4-carboxylate
- medicine
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cyclotransferase
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decyclization
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gamma-glutamyl-cysteine
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atp-hydrolyzing
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meister
Reaction
Synonyms
5-OPase, 5-oxo-L-prolinase, 5-oxoprolinase, 5OPase, ATP-dependent 5-oxoprolinase, FgOXP1, FgOXP2, FGSG_04902, FGSG_10203, L-pyroglutamate hydrolase, OPase, oplA, OPLAH, oxoprolinase, OXP1, PA4511, prokaryotic 5-oxoprolinase, PxpA, pxpA3, pxpB, pxpC, pyroglutamase, pyroglutamase (ATP-hydrolysing), pyroglutamate hydrolase, pyroglutamic hydrolase, SSO1667
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Application
Application on EC 3.5.2.9 - 5-oxoprolinase (ATP-hydrolysing)
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medicine
medicine
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clinical applications, substrate 5-oxo-L-proline sensitizes tumors to the alkylating agent melphalan
medicine
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animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity
medicine
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animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity
medicine
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5-oxoprolinuria is primarily associated with inborn errors of the gamma-glutamyl cycle
medicine
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occurrence of a futile cycle in patients with cystinosis. The enzyme gamma-glutamyl cysteine synthetase, in the absence of cysteine, forms 5-oxoproline instead of the normal substrate, gamma-glutamyl cysteine, and the 5-oxoproline is converted into glutamate by the ATP-dependant enzyme, 5-oxoprolinase. In cysteine-limiting conditions, glutamate is cycled back into glutamate via 5-oxoproline at the cost of two ATP molecules without production of glutathione and is the cause of the decreased levels of glutathione synthesis, as well as the ATP depletion observed in these cells
medicine
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animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity
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