3.5.2.5: allantoinase
This is an abbreviated version!
For detailed information about allantoinase, go to the full flat file.
Word Map on EC 3.5.2.5
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3.5.2.5
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allantoic
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ureide
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uricase
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allantoicase
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urate
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hydantoinase
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dihydropyrimidinase
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ureidoglycolate
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hydantoin
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imidase
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dihydroorotase
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amidohydrolases
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1.7.3.3
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diagnostics
- 3.5.2.5
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allantoic
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ureide
- uricase
- allantoicase
- urate
- hydantoinase
- dihydropyrimidinase
- ureidoglycolate
- hydantoin
- imidase
- dihydroorotase
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amidohydrolases
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1.7.3.3
- diagnostics
Reaction
Synonyms
AaALN, allantoin amidohydrolase, allantoinase, ALLase, AllBali, ALN, aln-1, aln-2, Fe-allantoinase, IsoI, IsoII, metal-dependent allantoinase, metal-independent allantoinase, Os04g0680400, OsALN, puuE, Salk_142607, Salk_146783, zinc-amended allantoinase
ECTree
Advanced search results
Engineering
Engineering on EC 3.5.2.5 - allantoinase
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D319A
site-directed mutagenesis, inactive mutant, altered thermal denaturation compared to the wild-type enzyme
D319N
site-directed mutagenesis, inactive mutant, altered thermal denaturation compared to the wild-type enzyme
S292A
site-directed mutagenesis, the mutant shows reduced activity and altered thermal denaturation compared to the wild-type enzyme
T155A
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
T155Y
site-directed mutagenesis, the mutant shows reduced activity and altered thermal denaturation compared to the wild-type enzyme
D319A
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site-directed mutagenesis, inactive mutant, altered thermal denaturation compared to the wild-type enzyme
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D319N
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site-directed mutagenesis, inactive mutant, altered thermal denaturation compared to the wild-type enzyme
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S292A
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site-directed mutagenesis, the mutant shows reduced activity and altered thermal denaturation compared to the wild-type enzyme
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T155A
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site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
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T155Y
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site-directed mutagenesis, the mutant shows reduced activity and altered thermal denaturation compared to the wild-type enzyme
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additional information
additional information
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a T-DNA insertion allantoinase mutant is unable to grow on 10 mM allantoin as the sole nitrogen source, although it still shows some root elongation with a few plants reaching the four-leaf stage, the mutant is rescued by a C-terminally tagged Arabidopsis thaliana AtAln variant, overview
additional information
downregulation of ALN and UO (uricase) genes impairing allantoin accumulation in Cd-treated Col-0 roots. In enzyme-deficient aln-3 roots, allantoin content increases nearly 2fold at 1 mM CdCl2 but is similar to untreated roots at 1.5 mM CdCl2. T-DNA insertions in allantoinase cause the constitutive accumulation of allantoin resulting in plant resistance to different abiotic stresses such as drought, salinity (NaCl), and heavy metal cadmium toxicity
additional information
generation of ALN-overexpressing (ALNox) lines. in ALNox lines the ALN gene expression increase leads to increased enzyme activity and suppressed allantoin accumulation. Therefore, ALNox Arabidopsis thaliana lines exhibit the opposite phenotype in comparison with aln-3 mutants, namely sensitivity to abiotic stress. The aln-3 enzyme-deficient mutant lines exhibit increased Cd tolerance
additional information
generation of knockout by T-DNA insertion, knockdown, and stress-inducible mutants for AtALN revealing that allantoin accumulation is essential for salt stress tolerance, phenotypes, overview
additional information
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generation of knockout by T-DNA insertion, knockdown, and stress-inducible mutants for AtALN revealing that allantoin accumulation is essential for salt stress tolerance, phenotypes, overview
additional information
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generation of knockout by T-DNA insertion, knockdown, and stress-inducible mutants for AtALN revealing that allantoin accumulation is essential for salt stress tolerance, phenotypes, overview
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additional information
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downregulation of ALN and UO (uricase) genes impairing allantoin accumulation in Cd-treated Col-0 roots. In enzyme-deficient aln-3 roots, allantoin content increases nearly 2fold at 1 mM CdCl2 but is similar to untreated roots at 1.5 mM CdCl2. T-DNA insertions in allantoinase cause the constitutive accumulation of allantoin resulting in plant resistance to different abiotic stresses such as drought, salinity (NaCl), and heavy metal cadmium toxicity
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additional information
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generation of ALN-overexpressing (ALNox) lines. in ALNox lines the ALN gene expression increase leads to increased enzyme activity and suppressed allantoin accumulation. Therefore, ALNox Arabidopsis thaliana lines exhibit the opposite phenotype in comparison with aln-3 mutants, namely sensitivity to abiotic stress. The aln-3 enzyme-deficient mutant lines exhibit increased Cd tolerance
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