3.5.2.3: dihydroorotase
This is an abbreviated version!
For detailed information about dihydroorotase, go to the full flat file.
Word Map on EC 3.5.2.3
-
3.5.2.3
-
pyrimidine
-
transcarbamoylase
-
carbamoyl-phosphate
-
phosphoribosyltransferase
-
atcase
-
orotidine
-
carbamoyltransferase
-
glutamine-dependent
-
l-dihydroorotate
-
2.1.3.2
-
cpsase
-
pyre
-
dihydropyrimidinase
-
hydantoinase
-
dihydro-ouabain
-
n-phosphonacetyl-l-aspartate
-
n-carbamyl-l-aspartate
-
allantoinase
-
imidase
-
synthesis
-
succinate-grown
-
amidohydrolases
-
6.3.5.5
-
drug development
-
medicine
-
5-fluoroorotate
- 3.5.2.3
- pyrimidine
-
transcarbamoylase
- carbamoyl-phosphate
- phosphoribosyltransferase
- atcase
- orotidine
-
carbamoyltransferase
-
glutamine-dependent
- l-dihydroorotate
-
2.1.3.2
- cpsase
-
pyre
- dihydropyrimidinase
- hydantoinase
- dihydro-ouabain
- n-phosphonacetyl-l-aspartate
-
n-carbamyl-l-aspartate
- allantoinase
- imidase
- synthesis
-
succinate-grown
-
amidohydrolases
-
6.3.5.5
- drug development
- medicine
- 5-fluoroorotate
Reaction
Synonyms
amidohydrolase family protein, BcDHOase, CAD, carbamoylaspartic dehydrase, Class I DHOase, DHO, DHOase, dihydroorotase, dihydroorotase domain, dihydroorotate dehydrolase, hDHOase, huDHOase, human DHOase domain, LdDHOase, More, pyrC, type I DHOase, type II DHO, VcDHO, YpDHO
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3.5.2.3 dihydroorotaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.2.3 - dihydroorotase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dexrazoxane + H2O
ADR-925
-
i.e. ICRF187 or (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane, cardioprotective agent
i.e. N,N-[(1S)-1-methyl-1,2-ethanediyl]bis[N-(2-amino-2-oxoethyl)glycine], biologically active form
?
N-(2-amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]glycine + H2O
N,N'-[(1S)-1-methyl-1,2-ethanediyl]bis[N-(2-amino-2-oxoethyl)]glycine
-
-
-
-
ir
N-(2-amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]glycine + H2O
N,N'-[(1S)-1-methyl-1,2-ethanediyl]bis[N-(2-amino-2-oxoethyl)]glycine
-
-
-
-
ir
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
-
aspartate transcarbamoylase-dihydroorotase complex
-
-
r
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
-
aspartate transcarbamoylase-dihydroorotase complex
-
-
r
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
-
absolute substrate specificity
-
-
?
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
Methanocaldococcus jannaschii ATCC 624773
-
-
-
-
r
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
-
-
-
r
(S)-dihydroorotate + H2O
N-carbamoyl-L-aspartate
-
-
-
r
L-carbamoylaspartate
L-dihydroorotate + H2O
-
-
-
-
r
N-carbamoyl-L-aspartate
(S)-dihydroorotate + H2O
preferred reaction direction
-
-
r
N-carbamoyl-L-aspartate
(S)-dihydroorotate + H2O
Leishmania donovani BHU 1081
preferred reaction direction
-
-
r
N-carbamoyl-L-aspartate
(S)-dihydroorotate + H2O
Methanocaldococcus jannaschii ATCC 624773
-
-
-
-
r
N-carbamoyl-L-aspartate
(S)-dihydroorotate + H2O
-
-
-
r
N-carbamoyl-L-aspartate
(S)-dihydroorotate + H2O
-
-
-
r
N-carbamoyl-L-aspartate
L-dihydroorotate + H2O
-
-
-
-
r
additional information
?
-
the DHOase reaction is reversible and pH-dependent
-
-
-
additional information
?
-
-
the DHOase reaction is reversible and pH-dependent
-
-
-
additional information
?
-
no substrate: hydantoin, dihydrouracil, phthalimide, and 3-imonoisoindolinone
-
-
?
additional information
?
-
-
no substrate: hydantoin, dihydrouracil, phthalimide, and 3-imonoisoindolinone
-
-
?
additional information
?
-
-
allantoin, hydantoin, and phthalimide are not hydrolyzed by dihydroorotase
-
-
?
additional information
?
-
N-carbamoyl-L-aspartate is preferred as the physiological substrate
-
-
-
additional information
?
-
malate can bind to the active site
-
-
-
additional information
?
-
N-carbamoyl-L-aspartate is preferred as the physiological substrate
-
-
-
additional information
?
-
malate can bind to the active site
-
-
-
additional information
?
-
N-carbamoyl-L-aspartate is preferred as the physiological substrate
-
-
-
additional information
?
-
malate can bind to the active site
-
-
-
additional information
?
-
N-carbamoyl-L-aspartate is preferred as the physiological substrate
-
-
-
additional information
?
-
-
N-carbamoyl-L-aspartate is preferred as the physiological substrate
-
-
-
