3.5.2.3: dihydroorotase

This is an abbreviated version!
For detailed information about dihydroorotase, go to the full flat file.

Word Map on EC 3.5.2.3

3.5.2.3

pyrimidine

transcarbamoylase

carbamoyl-phosphate

phosphoribosyltransferase

atcase

orotidine

carbamoyltransferase

glutamine-dependent

l-dihydroorotate

2.1.3.2

cpsase

pyre

dihydropyrimidinase

hydantoinase

dihydro-ouabain

n-phosphonacetyl-l-aspartate

n-carbamyl-l-aspartate

allantoinase

imidase

synthesis

succinate-grown

amidohydrolases

6.3.5.5

drug development

medicine

5-fluoroorotate

Reaction

Synonyms

amidohydrolase family protein, BcDHOase, CAD, carbamoylaspartic dehydrase, Class I DHOase, DHO, DHOase, dihydroorotase, dihydroorotase domain, dihydroorotate dehydrolase, hDHOase, huDHOase, human DHOase domain, LdDHOase, More, pyrC, type I DHOase, type II DHO, VcDHO, YpDHO

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.2 In cyclic amides

3.5.2.3 dihydroorotase

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Results	in table
5	Activating Compound
46170	AA Sequence
9	Application
1	CAS Registry Number
35	Cloned(Commentary)
17	Crystallization (Commentary)
71	Disease/ Diagnostics
48	General Information
8	IC50 Value
93	Inhibitors
15	kcat/KM [mM/s]
28	Ki Value [mM]
74	KM Value [mM]
1	Localization
27	Metals/Ions
41	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
91	Organism
7	Pathway
143	PDB ID
18	pH Optimum
5	pH Range
1	pH Stability
3	pI Value
3	Posttranslational Modification
48	Protein Variants
44	Purification (Commentary)
4	Reaction
3	Reaction Type
89	Reference
17	Source Tissue
18	Specific Activity [micromol/min/mg]
11	Storage Stability
105	Substrates and Products (Substrate)
51	Subunits
89	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
6	Temperature Range [°C]
8	Temperature Stability [°C]
29	Turnover Number [1/s]

KM Value

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KM Value on EC 3.5.2.3 - dihydroorotase

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0.02 - 0.6024

(S)-dihydroorotate

9 entries

0.51 - 15

carbamoyl aspartate

6 entries

0.076

dihydro-DL-orotate

Escherichia coli

246634

0.063 - 3.03

dihydroorotate

5 entries

0.015 - 2.2

L-carbamoylaspartate

7 entries

0.004 - 0.45

L-dihydroorotate

16 entries

0.285 - 6

N-(aminocarbonyl)-L-aspartic acid

7 entries

1.07

N-carbamoyl-DL-aspartate

Escherichia coli

246634

0.0281 - 24

N-carbamoyl-L-aspartate

12 entries

0.009 - 0.03

thiodihydroorotate

2 entries

additional information

carbamoyl aspartate

9 entries