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3.5.2.3: dihydroorotase

This is an abbreviated version!
For detailed information about dihydroorotase, go to the full flat file.

Word Map on EC 3.5.2.3

Reaction

(S)-dihydroorotate
+
H2O
=
N-carbamoyl-L-aspartate

Synonyms

amidohydrolase family protein, BcDHOase, CAD, carbamoylaspartic dehydrase, Class I DHOase, DHO, DHOase, dihydroorotase, dihydroorotase domain, dihydroorotate dehydrolase, hDHOase, huDHOase, human DHOase domain, LdDHOase, More, pyrC, type I DHOase, type II DHO, VcDHO, YpDHO

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.3 dihydroorotase

KI Value

KI Value on EC 3.5.2.3 - dihydroorotase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.3
(S)-1,2,3,6-tetrahydro-6-oxopyridine-2-carboxylic acid
-
with thio-dihydroorotate as substrate, pH. 8.0
0.0045 - 0.102
2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid
1.6
4(R)-hydroxy-6-oxo-piperidine-2(S)-carboxylic acid
-
with thio-dihydroorotate as substrate, pH. 8.0
3
4(S)-hydroxy-6-oxo-piperidine-2(S)-carboxylic acid
-
with thio-dihydroorotate as substrate, pH. 8.0
0.076 - 0.44
4,6-dioxo-piperidine-2-(S)-carboxylic acid
0.16 - 0.44
5-aminoorotate
1.46 - 2.6
5-bromoorotate
0.07 - 0.145
5-Fluoroorotate
3.5
5-iodoorotate
0.302 - 0.56
5-Methylorotate
0.0554
biotin sulfone
pH 8.0, 25°C, recombinant enzyme
0.1514
kaempferol
pH 8.0, 25°C, recombinant enzyme
0.66 - 0.95
Orotate