3.5.2.3: dihydroorotase
This is an abbreviated version!
For detailed information about dihydroorotase, go to the full flat file.
Word Map on EC 3.5.2.3
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3.5.2.3
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pyrimidine
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transcarbamoylase
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carbamoyl-phosphate
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phosphoribosyltransferase
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atcase
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orotidine
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carbamoyltransferase
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glutamine-dependent
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l-dihydroorotate
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2.1.3.2
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cpsase
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pyre
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dihydropyrimidinase
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hydantoinase
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dihydro-ouabain
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n-phosphonacetyl-l-aspartate
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n-carbamyl-l-aspartate
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allantoinase
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imidase
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synthesis
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succinate-grown
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amidohydrolases
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6.3.5.5
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drug development
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medicine
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5-fluoroorotate
- 3.5.2.3
- pyrimidine
-
transcarbamoylase
- carbamoyl-phosphate
- phosphoribosyltransferase
- atcase
- orotidine
-
carbamoyltransferase
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glutamine-dependent
- l-dihydroorotate
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2.1.3.2
- cpsase
-
pyre
- dihydropyrimidinase
- hydantoinase
- dihydro-ouabain
- n-phosphonacetyl-l-aspartate
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n-carbamyl-l-aspartate
- allantoinase
- imidase
- synthesis
-
succinate-grown
-
amidohydrolases
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6.3.5.5
- drug development
- medicine
- 5-fluoroorotate
Reaction
Synonyms
amidohydrolase family protein, BcDHOase, CAD, carbamoylaspartic dehydrase, Class I DHOase, DHO, DHOase, dihydroorotase, dihydroorotase domain, dihydroorotate dehydrolase, hDHOase, huDHOase, human DHOase domain, LdDHOase, More, pyrC, type I DHOase, type II DHO, VcDHO, YpDHO
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Application on EC 3.5.2.3 - dihydroorotase
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drug development
medicine
synthesis
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growth conditions which maintain DHOase overproduction require supplementation of Yeast Carbon Base with asparagines 5 g/l, glucose 20 g/l at pH 5.5. In this medium DHOase activity decreases with time, thus in terms of DHOase yield, the best time for harvesting cells is reached after 30 to 38 h of growth
the essential enzyme is a target for antibacterial drug design
drug development
the substantial difference between bacterial and mammalian DHOs makes the bacterial enzyme a promising drug target for disrupting bacterial growth and thus an important candidate to evaluate as a response to antimicrobial resistance on a molecular level
drug development
the substantial difference between bacterial and mammalian DHOs makes the bacterial enzyme a promising drug target for disrupting bacterial growth and thus an important candidate to evaluate as a response to antimicrobial resistance on a molecular level
drug development
-
the substantial difference between bacterial and mammalian DHOs makes the bacterial enzyme a promising drug target for disrupting bacterial growth and thus an important candidate to evaluate as a response to antimicrobial resistance on a molecular level
-
drug development
-
the essential enzyme is a target for antibacterial drug design
-
drug development
-
the substantial difference between bacterial and mammalian DHOs makes the bacterial enzyme a promising drug target for disrupting bacterial growth and thus an important candidate to evaluate as a response to antimicrobial resistance on a molecular level
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activation of the cardioprotective agent dexrazoxane by the enzyme in heart, mechanism