3.5.2.19: streptothricin hydrolase
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For detailed information about streptothricin hydrolase, go to the full flat file.
Reaction
Synonyms
sstH, sttH
ECTree
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General Information
General Information on EC 3.5.2.19 - streptothricin hydrolase
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malfunction
physiological function
construction of an sttH gene-knockout mutant. The minimum inhibitory concentration MIC of Streptothricins in the sttH gene-knockout mutant is determined to be 6.25 mg/ml, whereas the MIC of streptothricins in the Streptomyces albulus wild strain is determined to be above 400 mg/ml. This result clearly demonstrate that sttH is the sole gene responsible for streptothricin resistance in the Streptomyces albulus strain
malfunction
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construction of an sttH gene-knockout mutant. The minimum inhibitory concentration MIC of Streptothricins in the sttH gene-knockout mutant is determined to be 6.25 mg/ml, whereas the MIC of streptothricins in the Streptomyces albulus wild strain is determined to be above 400 mg/ml. This result clearly demonstrate that sttH is the sole gene responsible for streptothricin resistance in the Streptomyces albulus strain
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sttH gene is not essential for growth. The true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus
physiological function
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sttH gene is not essential for growth. The true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus
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