3.5.2.17: hydroxyisourate hydrolase
This is an abbreviated version!
For detailed information about hydroxyisourate hydrolase, go to the full flat file.
Word Map on EC 3.5.2.17
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3.5.2.17
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amyloidosis
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amyloid
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polyneuropathy
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cardiac
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fibril
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hereditary
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cardiomyopathy
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amyloidogenic
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neuropathy
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thyroxin
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albumin
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retinol
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tetramer
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nerve
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retinol-binding
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apolipoproteins
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senile
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alzheimer
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immunoglobulin
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cerebrospinal
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misfolding
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plexus
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scintigraphy
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ventricular
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choroid
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transferrin
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vitreous
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haptoglobin
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congo
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carpal
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amyloidogenesis
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echocardiography
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malnutrition
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late-onset
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prealbumin
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ejection
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light-chain
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csf
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endomyocardial
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medicine
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fibrillogenesis
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homotetrameric
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leptomeningeal
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gammopathy
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sensorimotor
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deiodinase
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orthostatic
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sural
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dysautonomia
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non-amyloidogenic
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portuguese
- 3.5.2.17
- amyloidosis
-
amyloid
- polyneuropathy
- cardiac
-
fibril
- hereditary
- cardiomyopathy
-
amyloidogenic
- neuropathy
- thyroxin
- albumin
- retinol
- tetramer
- nerve
-
retinol-binding
-
apolipoproteins
-
senile
- alzheimer
- immunoglobulin
-
cerebrospinal
- misfolding
- plexus
-
scintigraphy
- ventricular
- choroid
- transferrin
-
vitreous
- haptoglobin
-
congo
-
carpal
-
amyloidogenesis
-
echocardiography
- malnutrition
-
late-onset
-
prealbumin
-
ejection
- light-chain
- csf
-
endomyocardial
- medicine
-
fibrillogenesis
-
homotetrameric
- leptomeningeal
- gammopathy
-
sensorimotor
-
deiodinase
-
orthostatic
-
sural
- dysautonomia
-
non-amyloidogenic
-
portuguese
Reaction
Synonyms
5-HIUase, 5-hydroxyisourate hydrolase, ecTRP, HIU, HIU hydrolase, HIUase, HIUHase, HIUHase 1, hTTR, hydroxyisourate hydrolase, PucM, sbTTR, TLP, transthyretin, transthyretin-like protein, transthyretin-related protein, TRP, TTL, Urah
ECTree
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General Information
General Information on EC 3.5.2.17 - hydroxyisourate hydrolase
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evolution
metabolism
physiological function
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point mutation Y98Cin the gene encoding mouse HIU hydrolase, Urah, results in undetectable protein expression. Mice homozygous for this mutation develop elevated platelet counts secondary to excess thrombopoietin production and hepatomegaly. The majority of homozygous mutant mice also develop hepatocellular carcinoma, and tumor development is accelerated by exposure to radiation
the enzyme belongs to the 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses, overview. Teleosts have highly diverged genomes that resulted from whole genome duplication, which leads to an extensive diversity of paralogous genes. Transthyretin, an extracellular thyroid hormone binding protein, is thought to have evolved from an ancestral 5-hydroxyisourate hydrolase by gene duplication at some stage of chordate evolution. Phylogenetic analysis of the teleost aa sequences reveals the presence of two HIUHase subfamilies, HIUHase 1 (which has an N-terminal peroxisomal targeting signal-2) and HIUHase 2 (which does not have an N-terminal PTS2), and one transthyretin family
evolution
evolution of transthyretin from 5-hydroxyisourate hydrolase to triiodothyronine distributor to thyroxine distributor
evolution
sequential molecular events of functional trade-offs in 5-hydroxyisourate hydrolase before and after gene duplication led to the evolution of transthyretin during chordate diversification
evolution
sequential molecular events of functional trade-offs in 5-hydroxyisourate hydrolase before and after gene duplication led to the evolution of transthyretin during chordate diversification
the enzyme catalyzes the hydrolysis of 5-hydroxyisourate in the purine degradation pathway, and transthyretin, a thyroid hormone binding protein
metabolism
the enzymes is involved in uric acid metabolism