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3.5.2.17: hydroxyisourate hydrolase

This is an abbreviated version!
For detailed information about hydroxyisourate hydrolase, go to the full flat file.

Word Map on EC 3.5.2.17

Reaction

5-hydroxyisourate
+
H2O
=
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate

Synonyms

5-HIUase, 5-hydroxyisourate hydrolase, ecTRP, HIU, HIU hydrolase, HIUase, HIUHase, HIUHase 1, hTTR, hydroxyisourate hydrolase, PucM, sbTTR, TLP, transthyretin, transthyretin-like protein, transthyretin-related protein, TRP, TTL, Urah

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.17 hydroxyisourate hydrolase

General Information

General Information on EC 3.5.2.17 - hydroxyisourate hydrolase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
physiological function
-
point mutation Y98Cin the gene encoding mouse HIU hydrolase, Urah, results in undetectable protein expression. Mice homozygous for this mutation develop elevated platelet counts secondary to excess thrombopoietin production and hepatomegaly. The majority of homozygous mutant mice also develop hepatocellular carcinoma, and tumor development is accelerated by exposure to radiation