3.5.2.17: hydroxyisourate hydrolase
This is an abbreviated version!
For detailed information about hydroxyisourate hydrolase, go to the full flat file.
Word Map on EC 3.5.2.17
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3.5.2.17
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amyloidosis
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amyloid
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polyneuropathy
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cardiac
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fibril
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hereditary
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cardiomyopathy
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amyloidogenic
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neuropathy
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thyroxin
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albumin
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retinol
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tetramer
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nerve
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retinol-binding
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apolipoproteins
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senile
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alzheimer
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immunoglobulin
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cerebrospinal
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misfolding
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plexus
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scintigraphy
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ventricular
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choroid
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transferrin
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vitreous
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haptoglobin
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congo
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carpal
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amyloidogenesis
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echocardiography
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malnutrition
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late-onset
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prealbumin
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ejection
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light-chain
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csf
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endomyocardial
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medicine
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fibrillogenesis
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homotetrameric
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leptomeningeal
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gammopathy
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sensorimotor
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deiodinase
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orthostatic
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sural
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dysautonomia
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non-amyloidogenic
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portuguese
- 3.5.2.17
- amyloidosis
-
amyloid
- polyneuropathy
- cardiac
-
fibril
- hereditary
- cardiomyopathy
-
amyloidogenic
- neuropathy
- thyroxin
- albumin
- retinol
- tetramer
- nerve
-
retinol-binding
-
apolipoproteins
-
senile
- alzheimer
- immunoglobulin
-
cerebrospinal
- misfolding
- plexus
-
scintigraphy
- ventricular
- choroid
- transferrin
-
vitreous
- haptoglobin
-
congo
-
carpal
-
amyloidogenesis
-
echocardiography
- malnutrition
-
late-onset
-
prealbumin
-
ejection
- light-chain
- csf
-
endomyocardial
- medicine
-
fibrillogenesis
-
homotetrameric
- leptomeningeal
- gammopathy
-
sensorimotor
-
deiodinase
-
orthostatic
-
sural
- dysautonomia
-
non-amyloidogenic
-
portuguese
Reaction
Synonyms
5-HIUase, 5-hydroxyisourate hydrolase, ecTRP, HIU, HIU hydrolase, HIUase, HIUHase, HIUHase 1, hTTR, hydroxyisourate hydrolase, PucM, sbTTR, TLP, transthyretin, transthyretin-like protein, transthyretin-related protein, TRP, TTL, Urah
ECTree
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Engineering
Engineering on EC 3.5.2.17 - hydroxyisourate hydrolase
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R54E/Y119T
amino acid substitutions, R54E/Y119T, at the active sites of HIUHase, exert weak [125I]-3,3',5-triiodo-l-thyronine([125I]T3) binding activity with a concomitant loss of 5-hydroxyisourate hydrolysis activity
I16A
mutation at the active sites of HIUase, opens up one end of the channel that transverses the entire tetrameric protein, generating a cavity accessible to the thyroxine molecule and abrogating, at the same time, the enzymatic activity
I16A/Y116T
mutations at the active sites of HIUase open up the two ends of the channel that transverses the entire tetrameric protein, generating two cavities accessible to the thyroxine molecule and abrogating, at the same time, the enzymatic activity
Y116T
mutation at the active sites of HIUase, opens up one end of the channel that transverses the entire tetrameric protein, generating a cavity accessible to the thyroxine molecule and abrogating, at the same time, the enzymatic activity
E199A
E408A
Y98C
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point mutation in the gene encoding mouse HIU hydrolase, Urah, that perturbes uric acid metabolism within the liver. The substitution of cysteine for tyrosine in a conserved helical region results in undetectable protein expression. Mice homozygous for this mutation develop elevated platelet counts secondary to excess thrombopoietin production and hepatomegaly. The majority of homozygous mutant mice also develop hepatocellular carcinoma, and tumor development is accelerated by exposure to radiation
R54E/Y119T
amino acid substitutions, R54E/Y119T, at the active sites of HIUHase, exert weak [125I]-3,3',5-triiodo-l-thyronine([125I]T3) binding activity with a concomitant loss of 5-hydroxyisourate hydrolysis activity
additional information
E199A
site-directed mutagenesis, mutant devoid of detectable catalytic activity
E408A
site-directed mutagenesis, mutant devoid of detectable catalytic activity
the deletion mutation DELTAYRGS greatly affects activity
additional information
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the deletion mutation DELTAYRGS greatly affects activity