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3.5.2.1: barbiturase

This is an abbreviated version!
For detailed information about barbiturase, go to the full flat file.

Word Map on EC 3.5.2.1

Reaction

Barbiturate
+
H2O
=
3-oxo-3-ureidopropanoate

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.1 barbiturase

Systematic Name

Systematic Name on EC 3.5.2.1 - barbiturase

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SYSTEMATIC NAME
IUBMB Comments
barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)
Contains zinc and is specific for barbiturate as substrate [3]. Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.1.95 (N-malonylurea hydrolase). It was previously thought that the end-products of the reaction were malonate and urea but this has since been disproved [2]. May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9, uracil phosphoribosyltransferase.