3.5.1.B13: 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase
This is an abbreviated version!
For detailed information about 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase, go to the full flat file.
Reaction
Synonyms
polymyxin resistance protein pmrJ, undecaprenyl-phosphate-alpha-L-Ara4FN deformylase
ECTree
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Substrates Products
Substrates Products on EC 3.5.1.B13 - 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase
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REACTION DIAGRAM
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O
4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O
4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, the existence of a deformylase, acting later in the pathway, is postulated. The requirement of the ArnA formyltransferase reaction for the maintenance of polymyxin resistance suggests that an as yet unidentified deformylase must also exist, since neither L-Ara4N-modified lipid A nor the L-Ara4N donor, undecaprenyl phosphate-L-Ara4N, is formylated when isolated from polymyxin resistant cells
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