3.5.1.B13: 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase

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For detailed information about 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase, go to the full flat file.

Reaction

4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate

4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate

Synonyms

polymyxin resistance protein pmrJ, undecaprenyl-phosphate-alpha-L-Ara4FN deformylase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.B13 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase

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Natural Substrates Products on EC 3.5.1.B13 - 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase

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4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O

4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate

Escherichia coli

because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, the existence of a deformylase, acting later in the pathway, is postulated. The requirement of the ArnA formyltransferase reaction for the maintenance of polymyxin resistance suggests that an as yet unidentified deformylase must also exist, since neither L-Ara4N-modified lipid A nor the L-Ara4N donor, undecaprenyl phosphate-L-Ara4N, is formylated when isolated from polymyxin resistant cells

698730