3.5.1.96: succinylglutamate desuccinylase

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For detailed information about succinylglutamate desuccinylase, go to the full flat file.

Reaction

Synonyms

aruE, astE

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.96 succinylglutamate desuccinylase

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Results	in table
5346	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
5	Expression
6	General Information
1	KM Value [mM]
1	Metals/Ions
6	Organism
5	Pathway
1	pH Optimum
2	Protein Variants
1	Reaction
6	Reference
4	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 3.5.1.96 - succinylglutamate desuccinylase

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SYSTEMATIC NAME

IUBMB Comments

N-succinyl-L-glutamate amidohydrolase

Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).