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3.5.1.94: gamma-glutamyl-gamma-aminobutyrate hydrolase

This is an abbreviated version!
For detailed information about gamma-glutamyl-gamma-aminobutyrate hydrolase, go to the full flat file.

Reaction

4-(gamma-L-glutamylamino)butanoate
+
H2O
=
4-aminobutanoate
+
L-glutamate

Synonyms

PuuD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.94 gamma-glutamyl-gamma-aminobutyrate hydrolase

Systematic Name

Systematic Name on EC 3.5.1.94 - gamma-glutamyl-gamma-aminobutyrate hydrolase

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SYSTEMATIC NAME
IUBMB Comments
4-(glutamylamino)butanoate amidohydrolase
Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).