3.5.1.92: pantetheine hydrolase
This is an abbreviated version!
For detailed information about pantetheine hydrolase, go to the full flat file.
Word Map on EC 3.5.1.92
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3.5.1.92
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cysteamine
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pantothen
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gpi-anchored
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ectoenzyme
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pantothenamides
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gelatinase-associated
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walter
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aminothiol
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pantethine
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biotinidase
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julius
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medicine
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diagnostics
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drug development
- 3.5.1.92
- cysteamine
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pantothen
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gpi-anchored
-
ectoenzyme
- pantothenamides
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gelatinase-associated
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walter
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aminothiol
- pantethine
- biotinidase
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julius
- medicine
- diagnostics
- drug development
Reaction
Synonyms
GPI-80, PAGEL, pantetheinase, pantetheinase-associated gene expressed in leukocytes, pantetheinases, pantetheine hydrolase, vanin, vanin 1, vanin gene family, vanin-1, vanin-1 pantetheinase, vanin-2, vanin-3, vascular non-inflammatory molecule-1, vascular noninflammatory molecule 1, VNN-1, VNN1, Vnn1 pantetheinase, VNN2, VNN3
ECTree
3.5.1.92 pantetheine hydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.1.92 - pantetheine hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-pantetheine 4-phosphate + H2O
?
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10% of the activity with (R)-pantetheine
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?
2-(6-[[N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanyl]amino]-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + H2O
2-(6-amino-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanine
design, synthesis, and biological examination of a highly sensitive bioluminogenic probe for pantetheinase with a limit of detection of 1.14 ng/ml. Validation of the probe for application to detect the endogenous pantetheinase activity, overview
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ir
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O
6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate
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-
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?
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O
6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate
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-
-
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?
N,N'-bis(pantothenyl)-1,6-diaminohexane + H2O
?
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96% of the activity with (R)-pantetheine
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?
N-(4-methyl-2-oxo-2H-chromen-7-yl)-D-pantothenamide + H2O
(R)-pantothenate + 7-amino-4-methylcoumarin
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-
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?
S-pantetheine 3-pyruvate + H2O
S-cysteamine 3-pyruvate + pantothenate
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S-cysteamine 3-pyruvate spontaneously forms a cyclic product
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?
S-pantetheine-3-pyruvate + H2O
S-cysteamine-3-pyruvate + pantothenate
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S-cysteamine-3-pyruvate cyclizes in a non-rate-limiting step to give 2H-1,4-thiazin-5,6-dihydro-3-carboxylic acid, a compound exhibiting a strong absorption at 296 nm
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?
(R)-pantetheine + H2O
(R)-pantothenate + 2-aminoethanethiol
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?
(R)-pantetheine + H2O
(R)-pantothenate + 2-aminoethanethiol
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?
(R)-pantetheine + H2O
(R)-pantothenate + 2-aminoethanethiol
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-
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?
(R)-pantetheine + H2O
(R)-pantothenate + 2-aminoethanethiol
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?
pantetheine + H2O
pantothenic acid + cysteamine
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development of a highly sensitive fluorescent assay using a novel fluorescently labeled pantotheine derivative for high throughput screening for drug development and for quantification in various cell types and tissues
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?
pantothenate-7-amido-4-methylcoumarin + H2O
pantothenic acid + 7-amino-4-methylcoumarin
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based on LC-MS analysis, demonstrating that pantothenate-7-amido-4-methylcoumarin is hydrolyzed by vanin-1 at the amide-bond
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?
pantothenate-7-amido-4-methylcoumarin + H2O
pantothenic acid + 7-amino-4-methylcoumarin
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based on LC-MS analysis
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?
pantothenyl-beta-aminoethanol + H2O
?
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75% of the activity with (R)-pantetheine
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?
additional information
?
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membrane-bound pantetheinase is the main source of cysteamine in tissues under physiological conditions. The enzyme might by involved in the regulation of some immune functions maybe in the context of the response to oxidative stress
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?
additional information
?
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the transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. The sex- and cell-type-specific expression of vanin-1 in the developing mpouse gonad in vivo is required to provide an appropriate environment for male germ cell development
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?
additional information
?
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the vanin-1 gene is involved in testis development in mouse
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?
additional information
?
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vanin-1 is a key molecule to regulate the GSH-dependent response to oxidative injury in tissue at the epithelial level
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?
additional information
?
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vanin-1 plays a role in thymic reconstitution following damage by irradiation
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?
additional information
?
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vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions
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?
additional information
?
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vanin-1-/- mice are less susceptible to intestinal inflammation, either acute or chronic. Pantetheinase activity of vanin-1 is a major regulator of intestinal inflammation, acting through cysteamine release
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?
additional information
?
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vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection
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?
additional information
?
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vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes
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?
additional information
?
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vanin-1 regulates chondrogenesis via glutathione metabolism and is critical for accelerated chondrogenesis of ank/anf mesenchymal precursors and phosphate donor-driven chondrogenic transdifferentiation and calcification of aortic smooth muscle cells
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?
additional information
?
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vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells
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?
