3.5.1.92: pantetheine hydrolase

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For detailed information about pantetheine hydrolase, go to the full flat file.

Reaction

Synonyms

GPI-80, PAGEL, pantetheinase, pantetheinase-associated gene expressed in leukocytes, pantetheinases, pantetheine hydrolase, vanin, vanin 1, vanin gene family, vanin-1, vanin-1 pantetheinase, vanin-2, vanin-3, vascular non-inflammatory molecule-1, vascular noninflammatory molecule 1, VNN-1, VNN1, Vnn1 pantetheinase, VNN2, VNN3

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.92 pantetheine hydrolase

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Results	in table
12	Activating Compound
28	AA Sequence
12	Application
1	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
319	Disease/ Diagnostics
20	Expression
41	General Information
1	General Stability
6	IC50 Value
40	Inhibitors
3	Ki Value [mM]
6	KM Value [mM]
28	Localization
1	Metals/Ions
9	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
61	Organism
2	Pathway
12	PDB ID
9	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
9	Posttranslational Modification
14	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
52	Reference
102	Source Tissue
6	Specific Activity [micromol/min/mg]
3	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
100	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Crystallization

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Crystallization on EC 3.5.1.92 - pantetheine hydrolase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

purified recombinant FLAG-tagged truncated enzyme, and enzyme mutants E249Q and E439Q, free and in complex with pantothenic acid or inhibitor RR6, sitting drop vapor diffusion method, mixing of 200 nl of 12 mg/ml kifunensine-treated vanin 1 protein in 50 mM bis-tris pH 6.5, 50 mM NaCl, with 200 nl of reservoir solution containing 21% w/v PEG 1500, 10% v/v malate-MES-Tris, pH 6.3, with or without 1 mM pantothenic acid or inhibitor RR6, 25°C, 40-50 days, or 4 weeks after microseeding, X-ray diffraction structure determination and analysis at 2.25 A resolution, molecular replacement and modeling

Homo sapiens

O95497

733009