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3.5.1.91: N-substituted formamide deformylase

This is an abbreviated version!
For detailed information about N-substituted formamide deformylase, go to the full flat file.

Word Map on EC 3.5.1.91

Reaction

N-benzylformamide
+
H2O
=
formate
 +
benzylamine

Synonyms

NfdA

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.91 N-substituted formamide deformylase

Inhibitors

Inhibitors on EC 3.5.1.91 - N-substituted formamide deformylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
-
15% inhibition at 1 mM
2-mercaptoethanol
-
64% inhibition at 1 mM
3-Phenylpropylamine
-
inhibits the reverse enzyme reaction
8-hydroxyquinoline
AgNO3
aminoguanidine
-
19% inhibition at 1 mM
aniline
-
a benzylamine analogue, dead-end inhibition study, overview; inhibits the reverse enzyme reaction, uncompetitive versus benzylamine, competitive versus formate
Butyrate
-
slight inhibition of the reverse reaction, competitive versus benzylamine, noncompetitive versus formate
CdCl2
-
57% inhibition at 1 mM
CuCl2
dithiothreitol
H2O2
-
slight inhibition at 1 mM
HgCl2
Isobutyrate
-
slight inhibition of the reverse reaction
N-ethylmaleimide
o-phenanthroline
p-chloromercuribenzoate
phenethylamine
-
inhibits the reverse enzyme reaction
phenylhydrazine
Semicarbazide
-
8% inhibition at 1 mM
SnCl2
ZnCl2
0.25 mM, 25% inhibition
additional information
-
no or poor inhibition by 1 mM of LiCl, NaCl, MgCl2, CaCl2, BaCl2, MnCl2, AlCl3, Pb(NO3)2, FeSO4, FeCl3, RbCl, SrCl2, CsCl, Na2MoO4, CoCl2, NiCl2, and ZnCl2. No inhibition by iodoacetate, 5,5'-dithio-bis-2-nitrobenzoate, diethyldithiocarbamate, NaN3, and phenylmethanesulfonyl fluoride. Valerate, isovalerate, and caproate cannot be tested because they are insoluble in the reaction buffer
-