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3.5.1.88: peptide deformylase

This is an abbreviated version!
For detailed information about peptide deformylase, go to the full flat file.

Word Map on EC 3.5.1.88

Reaction

formyl-L-methionyl peptide
+
H2O
=
formate
 +
methionyl peptide

Synonyms

AtDEF1.1, AtDEF1.2, AtDEF2, AtPDF1A, AtPDF1B, AtPDF1Bt, AtPDF2, BbPDF, BcPDF, BcPDF2, DEF, Def1, DEF2, deformylase, peptide N-formylmethionine, EC 3.5.1.27, EcPDF, ECPDF1B, EfPDF, HpPDF, HsPDF, hydrolase, aminoacyl-transfer ribonucleate, LiPDF, mPDF, Ni-peptide deformylase, PDF, PDF-1, PDF-2, PDF1A, PDF1B, PDF2, PdfA, PdfB, PdfC, peptide deformylase, peptide deformylase 1, peptide deformylase 1A, peptide deformylase 1B, peptide deformylase 2, Pf PDF, PfPDF, Polypeptide deformylase, SaPDF, sPDF, TbPDF1, TbPDF2, type I PDF, type II PDF, type II peptide deformylase, Vp 16 PDF1B, Vp16 PDF, Vp16T, XOO1075, XoPDF

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.88 peptide deformylase

Turnover Number

Turnover Number on EC 3.5.1.88 - peptide deformylase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.17
formyl-L-Met-Leu-p-nitroanilide
-
-
0.0831
formyl-MAHA
-
0.00937
formyl-MEHQ
-
0.08 - 5
formyl-Met-Ala
0.57
formyl-Met-Ala-His-Ala-Ala-Gln
-
-
0.0081 - 332
formyl-Met-Ala-Ser
0.00046
formyl-Met-Leu-p-nitroanilide
-
-
1.5
formyl-Met-Thr-Gln-Ser-His
-
-
2.2
formyl-Met-Thr-Met-His-Thr-Thr
-
-
0.057
formyl-MFAD
-
0.0134
formyl-MFHQ
-
0.0155
formyl-MGHQ
-
0.00275
formyl-MLHQ
-
0.0049
formyl-MLKL
-
0.0646
formyl-MMYA
-
0.0502
formyl-MNFA
-
0.0211
formyl-MNPL
-
0.0283
formyl-MPQL
-
0.0202
formyl-MRHQ
-
0.0277 - 0.044
formyl-MTHQ
0.0362
formyl-MTMH
-
0.0174
formyl-MTPM
-
0.00581
formyl-MVHQ
-
0.45
N-formyl-1-(1-naphthyl)ethylamine
-
pH 7.2, 37°C
7.1
N-formyl-3-amino-3-phenylpropionic acid
-
pH 7.2, 37°C
0.22
N-formyl-alaninol
-
pH 7.2, 37°C
0.045
N-formyl-alpha-methyl-phenylglycine amide
-
pH 7.2, 37°C
26
N-formyl-beta-thiaphenylalanyl-Ala-Leu-4-nitroanilide
-
-
-
5.7
N-formyl-L-Ala-L-Ala-L-Ala
-
nickel-containing enzyme
-
140
N-formyl-L-Met-L-Ala-L-Ser
Co2+-substituted PDF-1, in 50 mM HEPES, pH 7.5, at 37°C
197
N-formyl-L-Met-L-Lys
-
nickel-containing enzyme
-
1370
N-formyl-m-methoxyphenylalanine nitrile
-
pH 7.2, 37°C
0.8 - 2100
N-formyl-Met-Ala
1030
N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg
-
-
0.07 - 210
N-formyl-Met-Ala-Ser
1.1 - 9.2
N-formyl-Met-Leu-Glu
1280 - 1320
N-formyl-Met-Leu-NH2
19 - 38
N-formyl-Met-Leu-p-nitroanilide
0.7
N-Formyl-Met-Leu-Phe
-
enzyme form PDF1A
1.9 - 175
N-formyl-Met-Ser-Asn-Glu
0.21
N-formyl-methionine
-
nickel-containing enzyme
270
N-formyl-Nle-Ala(NH2)
-
-
26 - 218
N-formyl-Nle-Ala-Ser
5 - 300
N-formyl-Nle-Arg(NH2)
320
N-formyl-Nle-Asn(NH2)
-
-
0.4 - 120
N-formyl-Nle-Asp(NH2)
280
N-formyl-Nle-Gln(NH2)
-
-
200
N-formyl-Nle-Glu(NH2)
-
-
1.4 - 260
N-formyl-Nle-Gly(NH2)
250
N-formyl-Nle-His(NH2)
-
-
0.36 - 150
N-formyl-Nle-Leu(NH2)
230
N-formyl-Nle-Lys(NH2)
-
-
190
N-formyl-Nle-Met(NH2)
-
-
210
N-formyl-Nle-Nle(NH2)
-
-
200
N-formyl-Nle-Phe(NH2)
-
-
150
N-formyl-Nle-Pro(NH2)
-
-
10 - 170
N-formyl-Nle-Ser(NH2)
180
N-formyl-Nle-Thr(NH2)
-
-
130
N-formyl-Nle-Trp(NH2)
-
-
140
N-formyl-Nle-Tyr(NH2)
-
-
160
N-formyl-Nle-Val(NH2)
-
-
18
N-formyl-Nva-Ala-Ser
-
enzyme form PDF1A
0.6
N-formyl-Phe-Ala-Ser
-
enzyme form PDF1A
204
N-formyl-Phe-Tyr-Phe-His-beta-Ala-Arg
-
-
880
N-formyl-phenylalanine nitrile
-
pH 7.2, 37°C
10.6
N-formyl-phenylglycine
-
pH 7.2, 37°C
227
N-formyl-phenylglycine amide
-
pH 7.2, 37°C
0.69 - 6.3
N-formyl-phenylglycinol
0.15
N-formyl-tert-leucine amide
-
pH 7.2, 37°C
3.5
N-formyl-thiaphenylalanyl-peptide
-
-
29.7
N-formyl-valine nitrile
-
pH 7.2, 37°C
4.2 - 70
N-formylmethionylleucyl-p-nitroanilide
additional information
additional information
-
-
-