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3.5.1.86: mandelamide amidase

This is an abbreviated version!
For detailed information about mandelamide amidase, go to the full flat file.

Reaction

(R)-mandelamide
+
H2O
=
(R)-mandelate
 +
NH3

Synonyms

amidase, mandelamide, MAH, mandelamide hydrolase, Pseudomonas mandelamide hydrolase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.86 mandelamide amidase

Inhibitors

Inhibitors on EC 3.5.1.86 - mandelamide amidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-phenyl-1,1,1-trifluoro-2-propanone
competitive
3-phenyl-1-chloro-2-propanone
competitive
benzyl (carbamoyloxy)carbamate
weak inhibition
N-(carbamoyloxy)benzamide
-
O-methoxycarbonylbenzohydroxamate
-
phenyl carbamate
-
phenylmethylboronic acid
a potent inhibitor of enzyme MAH that forms a transition state analogue structure with the enzyme
PMSF
1 mM, 80% inhibition
additional information
O-acyl hydroxamates are no irreversible inactivators of MAH but some are found to be transient inhibitors. Reactivity of MAH with some recently studied beta-lactamase inhibitors, overview
-