3.5.1.79: Phthalyl amidase

This is an abbreviated version!
For detailed information about Phthalyl amidase, go to the full flat file.

Reaction

Synonyms

Amidase, phthalyl, o-Phthalyl amidase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.79 Phthalyl amidase

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Results	in table
34	AA Sequence
6	Application
1	CAS Registry Number
1	Cloned(Commentary)
4	General Stability
9	Inhibitors
5	KM Value [mM]
3	Molecular Weight [Da]
5	Organism
2	pH Optimum
1	pH Range
3	Purification (Commentary)
2	Reaction
1	Reaction Type
5	Reference
2	Specific Activity [micromol/min/mg]
12	Substrates and Products (Substrate)
4	Subunits
2	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.5.1.79 - Phthalyl amidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-Carboxybenzoylamine-D-Phe-L-Ala

?

Xanthobacter agilis

-

-

31905, 31906

-

-

?

2-Carboxybenzoylamine-D-phenylglycine-methylester

?

Xanthobacter agilis

-

-

31905, 31906

-

-

?

2-Carboxybenzoylamine-L-Phe-L-Ala

?

Xanthobacter agilis

-

-

31905, 31906

-

-

?

7-Phthalamido-3-chloro-4-carboxy-1-carbadethioceph-3-em

Aspartame + phthalic acid

Xanthobacter agilis

-

i.e. phthalamindo carbacephem

31908

-

-

?

N-Phthalamido-L-Asp-L-Phe methyl ester

?

Xanthobacter agilis

-

-

31907

-

-

?

o-Phthalyl carbacephem

Loracarbef + phthalic acid

Xanthobacter agilis

-

-

31905

-

31905

?

[4-[(2-Carboxybenzoyl)amino]-1H-imidazol-1-yl]octanoic acid

?

Xanthobacter agilis

-

-

31905

-

-

?

additional information

?

-

2 entries

additional information

?

-

Xanthobacter agilis

-

substrate specificity: hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines. Substitutions allowed on the phthalyl group include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxyl group

31908

-

-

?

additional information

?

-

Xanthobacter agilis

-

broad specificity for o-phthalylated amides, absolute requirement for the o-phthalyl protecting group

31905

-

-

?