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3.5.1.78: Glutathionylspermidine amidase

This is an abbreviated version!
For detailed information about Glutathionylspermidine amidase, go to the full flat file.

Word Map on EC 3.5.1.78

Reaction

glutathionylspermidine
+
H2O
=
glutathione
 +
spermidine

Synonyms

Amidase, glutathionylspermidine, Glutathionylspermidine amidohydrolase (spermidine-forming), Glutathionylspermidine amidohydrolase [spermidine-forming], Glutathionylspermidine synthetase/amidase, GSP amidase, Gsp synthetase/amidase, GspA, GspSA, GSS, trypanothione synthetase-amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.78 Glutathionylspermidine amidase

Inhibitors

Inhibitors on EC 3.5.1.78 - Glutathionylspermidine amidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
gamma-Glu-Ala-Gly-CHO
-
most probably captures Cys59 and accumulates as the tetrahedral adduct in the amidase active site. Binding of phosphinophosphate in the Gsp synthetase active site potentiates the inhibition affinity for the aldehyde at the Gsp amidase active site by two orders of magnitude
iodoacetamide
-
-
L-gamma-glutamyl-5-azido-N-(3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxopropyl)-L-norleucinamide
-
L-gamma-glutamyl-5-azido-N-[3-(benzoyloxy)-2-oxopropyl]-L-norleucinamide
-
L-gamma-glutamyl-N-[3-(benzoyloxy)-2-oxopropyl]-6-[4-([[5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]-L-norleucinamide
-
Polyamine-containing phosphopeptides
-
potent and selective inhibitors, which selectively inhibit the synthetase domain over the amidase domain
-