3.5.1.77: N-carbamoyl-D-amino-acid hydrolase

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For detailed information about N-carbamoyl-D-amino-acid hydrolase, go to the full flat file.

Reaction

Synonyms

AcHyuC, Amidase, N-carbamoyl-D-amino acid, BJS_06659, carbamoylase, D-carbamoylase, D-N-alpha-Carbamoylase, D-N-carbamoylase, D-NCAase, Dcase, DCase-M3, DCHase, hyuD, N-carbamoyl D-amino acid amidohydrolase, N-Carbamoyl-D-amino acid amidase, N-carbamoyl-D-amino acid amidohydrolase, N-Carbamyl amino acid amidohydrolase, N-Carbamyl-D-amino acid amidohydrolase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.77 N-carbamoyl-D-amino-acid hydrolase

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Results	in table
1241	AA Sequence
17	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
8	General Information
4	General Stability
62	Inhibitors
2	kcat/KM [mM/s]
42	KM Value [mM]
12	Metals/Ions
16	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
68	Organism
3	Oxidation Stability
18	PDB ID
10	pH Optimum
6	pH Range
4	pH Stability
140	Protein Variants
17	Purification (Commentary)
1	Reaction
3	Reaction Type
48	Reference
1	Renatured (Commentary)
2	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
121	Substrates and Products (Substrate)
30	Subunits
46	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
7	Temperature Range [°C]
29	Temperature Stability [°C]
21	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.5.1.77 - N-carbamoyl-D-amino-acid hydrolase

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SYSTEMATIC NAME

IUBMB Comments

N-carbamoyl-D-amino-acid amidohydrolase

This enzyme, along with EC 3.5.1.87 (N-carbamoyl-L-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the "hydantoinase process", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [2]. It has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or on the N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.