3.5.1.74: chenodeoxycholoyltaurine hydrolase

This is an abbreviated version!
For detailed information about chenodeoxycholoyltaurine hydrolase, go to the full flat file.

Reaction

Synonyms

CTH, hydrolase, chenodeoxychoyltaurine

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.74 chenodeoxycholoyltaurine hydrolase

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Results	in table
1	Activating Compound
1	AA Sequence
1	CAS Registry Number
4	Inhibitors
1	KM Value [mM]
2	Molecular Weight [Da]
2	Organism
2	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
2	Reference
8	Specific Activity [micromol/min/mg]
1	Storage Stability
17	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.5.1.74 - chenodeoxycholoyltaurine hydrolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

tauro (3alpha,5beta,7beta,12alpha)-3,7,12-trihydroxycholan-24-oic amide + H2O

taurine + (3alpha,5beta,7beta,12alpha)-3,7,12-trihydroxycholan-24-oic acid

Phocaeicola vulgatus

-

0.5% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

tauro-beta-muricholic acid + H2O

taurine + beta-muricholic acid

Phocaeicola vulgatus

-

62% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

taurochenodeoxycholic acid + H2O

chenodeoxycholate + taurine

2 entries

taurocholic acid + H2O

taurine + cholic acid

Phocaeicola vulgatus

-

2.8% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

taurodeoxycholic acid + H2O

taurine + deoxycholic acid

Phocaeicola vulgatus

-

31% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

taurohyocholic acid + H2O

taurine + hyocholic acid

Phocaeicola vulgatus

-

24% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

taurohyodeoxycholic acid + H2O

taurine + hyodeoxycholic acid

Phocaeicola vulgatus

-

36% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

tauroursodeoxycholic acid + H2O

taurine + ursodeoxycholic acid

Phocaeicola vulgatus

-

56% of activity compared to taurochenodeoxycholic acid

209234

-

-

?

additional information

?

-

8 entries

taurochenodeoxycholic acid + H2O

chenodeoxycholate + taurine

Phocaeicola vulgatus

-

best substrate

209234

-

-

?

taurochenodeoxycholic acid + H2O

chenodeoxycholate + taurine

Phocaeicola vulgatus VI-31

-

best substrate

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus

-

substrate specificity

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus

-

hydrolyzes taurine-conjugated bile acids, glycine-conjugated bile acids are no substrates

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus

-

no activity with glycocholic acid, glyco-7beta-cholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, glyco-beta-muricholic acid, glycoursodeoxycholic acid, glycohyocholic acid, glycohyodeoxycholic acid

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus

-

specificity for not only the amino acid moiety but also the steroidal moiety

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus VI-31

-

substrate specificity

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus VI-31

-

hydrolyzes taurine-conjugated bile acids, glycine-conjugated bile acids are no substrates

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus VI-31

-

no activity with glycocholic acid, glyco-7beta-cholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, glyco-beta-muricholic acid, glycoursodeoxycholic acid, glycohyocholic acid, glycohyodeoxycholic acid

209234

-

-

?

additional information

?

-

Phocaeicola vulgatus VI-31

-

specificity for not only the amino acid moiety but also the steroidal moiety

209234

-

-

?