3.5.1.62: acetylputrescine deacetylase

This is an abbreviated version!
For detailed information about acetylputrescine deacetylase, go to the full flat file.

Reaction

Synonyms

acetylpolyamine amidohydrolase, APAH, APAH1, APAH2, AphA, AphB, PA0321, PA1409, polyamine deacetylase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.62 acetylputrescine deacetylase

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Results	in table
10	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
13	General Information
7	IC50 Value
19	Inhibitors
11	KM Value [mM]
8	Metals/Ions
1	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
20	Organism
2	Pathway
26	PDB ID
4	pH Optimum
16	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
1	Specific Activity [micromol/min/mg]
57	Substrates and Products (Substrate)
1	Subunits
85	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.5.1.62 - acetylputrescine deacetylase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-amino-N-hydroxypentanamide

Mycoplana ramosa

Q48935

-

752759

5-[(3-aminopropyl)amino]pentane-1-thiol

Mycoplana ramosa

Q48935

-

752759

6-amino-N-hydroxyhexanamide

Mycoplana ramosa

Q48935

-

752759

6-[(3-aminopropyl)amino]-N-hydroxyhexanamide

Mycoplana ramosa

Q48935

-

752759

7-amino-N-hydroxyheptanamide

Mycoplana ramosa

Q48935

-

752759

7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one

2 entries

8-amino-N-hydroxyoctanamide

Mycoplana ramosa

Q48935

-

752759

8-hydroxyquinoline

Micrococcus luteus

-

very slight inhibition, 1 mM: 2% inhibition

172070

Ca2+

Micrococcus luteus

-

1 mM: 6.2% inhibition

172070

CaCl2

Micrococcus luteus

-

1 mM: 6.2% inhibition

172070

Cu2+

Micrococcus luteus

-

1 mM: 74.4% inhibition

172070

CuCl2

Micrococcus luteus

-

1 mM: 74.4% inhibition

172070

iodoacetamide

Micrococcus luteus

-

very slight inhibition, 1 mM: 2% inhibition

172070

Ni2+

Micrococcus luteus

-

1 mM: 66.8% inhibition

172070

NiCl2

Micrococcus luteus

-

1 mM: 66.8% inhibition

172070

p-chloromercuribenzoic acid

Micrococcus luteus

-

very slight inhibition, 1 mM: 2% inhibition

172070

additional information

2 entries

-

7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one

Mycoplana ramosa

Q48935

AAT, an analogue of N8-acetylspermidine

752759

7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one

Mycoplana ramosa

Q48935

AAT, binds as a tetrahedral gem-diolate to both APAH and HDAC10 (histone 10 deacetylase, EC 3.5.1.48), thereby mimicking the tetrahedral intermediate and its flanking transition states in catalysis

752780

additional information

Micrococcus luteus

-

no or very slight inhibition by -SH blocking agents

172070

-

additional information

Mycoplana ramosa

Q48935

design, synthesis, and evaluation of polyamine deacetylase inhibitors, and high-resolution crystal structures of their complexes with acetylpolyamine amidohydrolase, overview

752759

-