3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase
This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.
Reaction
Synonyms
acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase
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General Information
General Information on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase
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evolution
malfunction
physiological function
additional information
the enzyme is a cysteine amidase that belongs to the N-terminal nucleophile (Ntn) family of enzymes and is characterized by a conserved amino acid catalytic triad Cys, Arg, and Asp
evolution
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the enzyme is a cysteine hydrolase belonging to the N-terminalnucleophile (Ntn) family of enzymes
evolution
the enzyme is a cysteine hydrolase belonging to the N-terminalnucleophile (Ntn) family of enzymes
evolution
the enzyme is a cysteine hydrolase belonging to the N-terminalnucleophile (Ntn) family of enzymes
enzyme inhibitors may attenuate heat hyperalgesia and mechanical allodynia caused by local inflammation or nerve damage in animal models of pain and inflammation
malfunction
enzyme inhibitors may attenuate heat hyperalgesia and mechanical allodynia caused by local inflammation or nerve damage in animal models of pain and inflammation
malfunction
effects of pretreatment with the NAAA inhibitor AM11095 on nicotine-related effects in the rat mesolimbic dopamine system, phenotype, detailed overview
malfunction
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N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis
malfunction
pharmacological inhibitors of NAAA activity exert profound analgesic and antiinflammatory effects
malfunction
prevention against cartilage degeneration by i.p. injection of enzyme inhibitor F215 in osteoarthritis rats
malfunction
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effects of pretreatment with the NAAA inhibitor AM11095 on nicotine-related effects in the rat mesolimbic dopamine system, phenotype, detailed overview
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malfunction
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N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis
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N-acylethanolamine-hydrolyzing acid amidase is a lysosomal enzyme that primarily degrades palmitoylethanolamine, a lipid amide that inhibits inflammatory responses
physiological function
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the enzyme intracellularly breaks down the analgesic and anti-inflammatory mediator palmitoylethanolamide
physiological function
the enzyme intracellularly breaks down the analgesic and anti-inflammatory mediator palmitoylethanolamide
physiological function
the enzyme intracellularly breaks down the analgesic and anti-inflammatory mediator palmitoylethanolamide
physiological function
important role for NAAA in cell migration and in inducing tumor cell death promoting this enzyme as pharmacological target against bladder cancer
physiological function
N-acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid signaling molecules that includes oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)
physiological function
N-acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid signaling molecules that includes oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)
physiological function
-
N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase that catalyzes the degradation of palmitoylethanolamide. Palmitoylethanolamide is an agonist of PPAR-alpha and an important regulator of pain and innate immunity
physiological function
the enzyme is implicated in osteoarthritis progression
physiological function
the enzyme is implicated in osteoarthritis progression
physiological function
-
N-acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid signaling molecules that includes oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)
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physiological function
-
N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase that catalyzes the degradation of palmitoylethanolamide. Palmitoylethanolamide is an agonist of PPAR-alpha and an important regulator of pain and innate immunity
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the catalytic triad, is formed by cysteine, aspartate and arginine
additional information
residues Leu325 and Thr335 are catalytically important for isozyme A, and the latter one is indispensable for the enzyme activity of NAAA
additional information
structure analysis of the enzme in complex with myristate, substrate binding structure, overview. The enzyme must disrupt the membrane to reach its embedded substrate, and helices alpha3 and alpha6 are likely candidates for this function
additional information
the enzyme must disrupt the membrane to reach its embedded substrate, and helices alpha3 and alpha6 are likely candidates for this function
additional information
the enzyme must disrupt the membrane to reach its embedded substrate, and helices alpha3 and alpha6 are likely candidates for this function
additional information
the enzyme must disrupt the membrane to reach its embedded substrate, and helices alpha3 and alpha6 are likely candidates for this function. Detergent-induced rearrangement generates the NAAA substrate-binding site