3.5.1.36: N-methyl-2-oxoglutaramate hydrolase

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For detailed information about N-methyl-2-oxoglutaramate hydrolase, go to the full flat file.

5-hydroxy-N-methylpyroglutamate synthase, 5-hydroxy-N-methylpyroglutamate synthetase

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Results	in table
5	Activating Compound
1	CAS Registry Number
14	Inhibitors
6	KM Value [mM]
1	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
36	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
3	Reaction Type
8	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
10	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Activating Compound on EC 3.5.1.36 - N-methyl-2-oxoglutaramate hydrolase

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acetone

noncompetitive activator with respect to ethanolamine

aliphatic alcohols

7fold increase of hydrolysis of alpha-ketoglutaramate and ethyl alpha-ketoglutarate

Dimethyl formamide

noncompetitive activator with respect to ethanolamine

dioxane

noncompetitive activator, effect on the reaction of methylamine with ethyl alpha-ketoglutarate

organic solvents

increase both hydrolysis and transfer reactions involving amines, accelerated up to 7fold