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3.5.1.28: N-acetylmuramoyl-L-alanine amidase

This is an abbreviated version!
For detailed information about N-acetylmuramoyl-L-alanine amidase, go to the full flat file.

Word Map on EC 3.5.1.28

Reaction

GlcNAc-MurNAc-L-Ala-D-isoglutaminyl-meso-diaminopimelyl-D-Ala-D-Ala
+
H2O
=
N-acetylglucosaminyl-N-acetylmuramic acid
 +
L-Ala-D-isoglutaminyl-meso-diaminopimelyl-D-Ala-D-Ala

Synonyms

1,6-anhydro-N-acetylmuramic acid-L-alanine amidase, 1,6-anhydro-N-acetylmuramyl-L-alanine amidase, acetylmuramoyl-alanine amidase, acetylmuramyl-alanine amidase, acetylmuramyl-L-alanine amidase, AMI1, AmiA, AmiB, AmiC, AmiC2, AmiD, amidase 3, amidase-hydrolase, AmiE, AmpD, anhydroMurNAc-L-Ala amidase, AtlE, Autolysin, autolysin E, bacteriophage phiGVE2 amidase, cell separation amidase, cell wall amidase, Cell wall hydrolase, CwhA, CwlB protein, cwlC, CwlJ1, EC 3.4.17.7, EC 3.4.19.10, endolysin, GC-AmiC, GRCS_0011, LysBPS13, lysostaphin, LysSA97, LytA, LytA-like N-acetylmuramoyl-L-alanine amidase, LytAB6, LytAHER, Lytic amidase, Lytmu1/6, LytN, More, MSMEG_6281, Mtb peptidoglycan amidase, Mucopeptide aminohydrolase, murein hydrolase, MurnAc-lAA, Nacetylmuramoyl-L-alanine amidase activity, N-acetyl muramyl-L-alanine amidase, N-acetyl-muramoyl-L-alanine amidase, N-acetylmuramic acid L-alanine amidase, N-acetylmuramoyl-L-alanine amidase, N-acetylmuramoyl-l-alanine amidase B, N-acetylmuramoyl-L-alanine amidase type I, N-acetylmuramoyl-L-alanine amidase type II, N-acetylmuramyl-L-alanine amidase, N-acetylmuramylalanine amidase, N-acylmuramyl-L-alanine amidase, NAM-amidase, NAMLA amidase, NAMLAA, Npun_F1846, ORFL3, peptidoglycan amidase, peptidoglycan aminohydrolase, Peptidoglycan hydrolase, peptidoglycan recognition protein 2, peptidoglycan recognition protein SC1a, peptidoglycan recognition protein-L, PG amidase, PGLYRP2, PGRP, PGRP-L, PGRP-S4, PGRP-SB1, phage endolysin, phi26F_gp22, phiCP26F endolysin, phiGVE2 endolysin, PlyCP26F, PlyCP39O, PlyCpAmi, PlyGRCS, PlyPl23, RC0497, RS15875, Rv3717, SA97_036, short peptidoglycan recognition protein 4, Skl, Sle1, SleC, spore cortex lytic enzyme, T3 lysozyme, T7 lysozyme

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.28 N-acetylmuramoyl-L-alanine amidase

Disease

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Disease on EC 3.5.1.28 - N-acetylmuramoyl-L-alanine amidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Bacterial Infections
Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus.
Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.
[Cloning of T7 lysozyme gene and construction of the vector for transgenic plants resistant to bacterial infection]
Carcinoma, Hepatocellular
Tumor-Derived PGLYRP2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
Cardiovascular Diseases
PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
Cholera
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response.
Colitis
Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis.
Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.
Colorectal Neoplasms
CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?
Dyslipidemias
PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
Endophthalmitis
Intravitreal injection of the chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis.
Erythema
Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease.
Foodborne Diseases
Endolysin LysSA97 is synergistic with carvacrol in controlling Staphylococcus aureus in foods.
Glioblastoma
CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?
Hepatitis C
Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease.
Hypersensitivity
Specificity in transcriptional regulation in the absence of specific DNA binding sites: the case of T7 lysozyme.
Infections
A mutation in the yeast mitochondrial core RNA polymerase, Rpo41, confers defects in both specificity factor interaction and promoter utilization.
A novel STK1-targeted small-molecule as an "antibiotic resistance breaker" against multidrug-resistant Staphylococcus aureus.
A Peptidoglycan Amidase Activator Impacts Salmonella enterica Serovar Typhimurium Gut Infection.
Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1.
Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections.
Cloning, mRNA expression, and recombinant expression of peptidoglycan recognition protein II gene from large yellow croaker (Pseudosciaena crocea).
Comparative secretome investigation of Magnaporthe oryzae proteins responsive to nitrogen starvation.
Drosophila melanogaster mounts a unique immune response to the Rhabdovirus sigma virus.
Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection.
Evolution, purification, and characterization of RC0497: a peptidoglycan amidase from the prototypical spotted fever species Rickettsia conorii.
Evolutionary robustness of an optimal phenotype: re-evolution of lysis in a bacteriophage deleted for its lysin gene.
Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications.
Multiple roles of T7 RNA polymerase and T7 lysozyme during bacteriophage T7 infection.
Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection.
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.
Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.
Studies on the role of bacteriophage T7 lysozyme during phage infection.
The depression of endolysin synthesis in bacteria infected with high multiplicities of phage lambda.
The Efficacy of Intranasal Administration of the Recombinant Endolysin, SAL200, in a Lethal Murine Staphylococcus aureus Pneumonia Model.
The germination-specific lytic enzymes SleB, CwlJ1, and CwlJ2 each contribute to Bacillus anthracis spore germination and virulence.
Leukemia, Myeloid, Acute
Expression and intracellular localization of the human N-acetylmuramyl-L-alanine amidase, a bacterial cell wall-degrading enzyme.
Leukemia-Lymphoma, Adult T-Cell
Characterization of AtlL, a bifunctional autolysin of Staphylococcus lugdunensis with N-acetylglucosaminidase and N-acetylmuramoyl-l-alanine amidase activities.
Lupus Erythematosus, Systemic
PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
Lyme Disease
Transcription and genetic analyses of a putative N-acetylmuramyl-L-alanine amidase in Borrelia burgdorferi.
Meningitis, Bacterial
Differences in N-acetylmuramyl-L-alanine amidase and lysozyme in serum and cerebrospinal fluid of patients with bacterial meningitis.
Neoplasms
Tumor-Derived PGLYRP2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
Persistent Infection
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.
Pneumococcal Infections
Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection.
Rickettsia Infections
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.
Sepsis
Proteomic profiling identifies N-acetylmuramoyl-l-alanine amidase as a novel biomarker of sepsis.
Spotted Fever Group Rickettsiosis
Evolution, purification, and characterization of RC0497: a peptidoglycan amidase from the prototypical spotted fever species Rickettsia conorii.
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.
Staphylococcal Food Poisoning
Characteristics for phage-encoded cell wall hydrolase of LysSAP27 to reduce staphylococcal food poisoning.
Staphylococcal Infections
Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1.
Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection.
Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.
The Efficacy of Intranasal Administration of the Recombinant Endolysin, SAL200, in a Lethal Murine Staphylococcus aureus Pneumonia Model.
Starvation
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response.
Expressions of alkaline phosphatase genes during phosphate starvation are under positive influences of multiple cell wall hydrolase genes in Bacillus subtilis.
Investigation of antibacterial mechanism and identification of bacterial protein targets mediated by antibacterial medicinal plant extracts.
Tuberculosis
Effect of Mycobacterium tuberculosis Rv3717 on cell division and cell adhesion.
Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase.
Mycobacterium tuberculosis Rv3717 enhances the survival of Mycolicibacterium smegmatis by inhibiting host innate immune and caspase-dependent apoptosis.
Structural and biochemical analyses of Mycobacterium tuberculosis N-acetylmuramyl L-alanine amidase Rv3717 point to a role in peptidoglycan fragment recycling.
The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.
Tuberculosis, Multidrug-Resistant
Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
Typhus, Epidemic Louse-Borne
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.
Vaginosis, Bacterial
Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo.