3.5.1.26: N4-(beta-N-acetylglucosaminyl)-L-asparaginase
This is an abbreviated version!
For detailed information about N4-(beta-N-acetylglucosaminyl)-L-asparaginase, go to the full flat file.
Word Map on EC 3.5.1.26
-
3.5.1.26
-
lysosomal
-
aspartylglucosaminuria
-
lepidoptera
-
mitogenome
-
protein-coding
-
microsatellite-like
-
attta
-
poly-a
-
butterfly
-
a+t-rich
-
glycoasparagines
-
nymphalidae
-
aspartylglucosamine
-
dihydrouridine
-
trnaseragn
-
autoproteolysis
-
meningosepticum
-
hesperiidae
-
papilionidae
-
lrrna
-
pieridae
-
non-finnish
-
glcnac-asn
-
clover-leaf
-
medicine
-
lycaenidae
-
trnamet
-
diagnostics
- 3.5.1.26
- lysosomal
- aspartylglucosaminuria
- lepidoptera
-
mitogenome
-
protein-coding
-
microsatellite-like
-
attta
- poly-a
- butterfly
-
a+t-rich
- glycoasparagines
- nymphalidae
- aspartylglucosamine
- dihydrouridine
-
trnaseragn
-
autoproteolysis
- meningosepticum
- hesperiidae
- papilionidae
-
lrrna
- pieridae
-
non-finnish
- glcnac-asn
-
clover-leaf
- medicine
- lycaenidae
- trnamet
- diagnostics
Reaction
Synonyms
1-aspartamido-beta-N-acetylglucosamine amidohydrolase, 4-L-aspartylglucosylamine amido hydrolase, AGA, amidase-1, amidase-2, amidase-3, aspartylglucosaminidase, aspartylglucosylaminase, aspartylglucosylamine deaspartylase, aspartylglycosylamine amidohydrolase, AtAGA, beta-aspartylglucosylamine amidohydrolase, EC 3.5.1.37, GA, glucosylamidase, glycoasparaginase, glycosylasparaginase, LhAGA, More, N-aspartyl-beta-glucosaminidase, N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
ECTree
3.5.1.26 N4-(beta-N-acetylglucosaminyl)-L-asparaginaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.5.1.26 - N4-(beta-N-acetylglucosaminyl)-L-asparaginase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-[alpha-D-Man-(1-3)-alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc-(1-4)-beta-D-GlcNAc]-L-aspartate + H2O
alpha-D-Man-(1-3)-alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc-(1-4)-beta-D-GlcNAc + L-aspartate
-
fast hydrolysis rate
-
?
N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine + H2O
?
-
catabolism of N-linked oligosaccharides
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
N4-(beta-N-acetylglucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
deficiency in the activity of human GA leads to a lysosomal storage disease aspartylglycosaminuria
-
-
?
N4-(beta-N-acetylglucosaminyl)-L-asparagine + H2O
N-acetyl-D-glucosaminylamine + L-aspartate
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
low activity
-
?
L-asparagine + H2O
L-aspartate + NH3
-
21% activity compared to N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine as substrate
-
r
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
preferred substrate
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
belongs to N-terminal nucleophile hydrolase family
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
involved in degradation of glycoproteins
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
involved in degradation of glycoproteins
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
involved in degradation of glycoproteins
-
r
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
-
-
?
additional information
?
-
AGA hydrolyzes the beta-N glycosidic linkage between the asparagines residue and the N-acetylglucosamine moiety. The enzyme fails to exhibit any glycopeptide N-glycosidase activity toward entire glycoproteins like fetuin, its activity is restricted to the deglycosylation of free glycosylasparagines like human aspartylglucosaminidase
-
-
?
additional information
?
-
-
AGA hydrolyzes the beta-N glycosidic linkage between the asparagines residue and the N-acetylglucosamine moiety. The enzyme fails to exhibit any glycopeptide N-glycosidase activity toward entire glycoproteins like fetuin, its activity is restricted to the deglycosylation of free glycosylasparagines like human aspartylglucosaminidase
-
-
?
additional information
?
-
-
glycosylasparaginase protein is synthesized as a single-chain precursor (inhibitor-free precursor) and requires a cis proteolysis of its own main-chain amide bond, splitting it into two subunits. Once autocleaved, the mature glycosylasparaginase with a free amino end exposed at Thr152 becomes active in glycoprotein degradation by binding to and processing its glycoasparagine substrate
-
-
?
additional information
?
-
-
enzyme catalyzes the hydrolysis of the N-glycosylic bond between asparagine and N-acetylglucosamine in the catabolism of N-linked glycoproteins
-
-
?
additional information
?
-
aspartylglucosaminuria, a lysosomal storage disease caused by mutation L15R, is enriched in the Finnish population
-
-
?
additional information
?
-
-
aspartylglucosaminuria, a lysosomal storage disease caused by mutation L15R, is enriched in the Finnish population
-
-
?
additional information
?
-
-
enzyme level in plasma is elevated in congenital disorders of glycosylation type I, CDG I, a defect in biosynthesis or processing of O-linked glycans, overview
-
-
?
