3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-phosphate deacetylase, go to the full flat file.

Reaction

Synonyms

2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase, acetylaminodeoxyglucosephosphate acetylhydrolase, acetylglucosamine phosphate deacetylase, CaNAG2/Dac1, deacetylase, acetylglucosaminephosphate, EC 3.5.1.80, GlcNAc 6-P deacetylase, GlcNAc-6-phosphate deacetylase, GlnNAc6P deacetylase, Lmo0956, Lmo0956 protein, Lmo2108, Lmo2108 protein, MMNagA, MSNagA, N-acetyl-D-glucosamine-6-phosphate deacetylase, N-acetylglucosamine 6-phosphate deacetylase, N-acetylglucosamine-6-P deacetylase, N-acetylglucosamine-6-phosphate de-N-acetylase, N-acetylglucosamine-6-phosphate deacetylase, NAG2, NagA, NAGPase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase

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Results	in table
15372	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
6	Crystallization (Commentary)
4	Disease/ Diagnostics
20	General Information
1	General Stability
43	Inhibitors
10	kcat/KM [mM/s]
2	Ki Value [mM]
59	KM Value [mM]
7	Localization
18	Metals/Ions
13	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
49	Organism
10	Pathway
30	PDB ID
10	pH Optimum
4	pH Range
1	pH Stability
2	Posttranslational Modification
12	Protein Variants
14	Purification (Commentary)
6	Reaction
1	Reaction Type
39	Reference
7	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
73	Substrates and Products (Substrate)
17	Subunits
42	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
52	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.5.1.25 - N-acetylglucosamine-6-phosphate deacetylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-glucosamine 6-phosphate + acetate

N-acetyl-D-glucosamine 6-phosphate + H2O

2 entries

N-acetyl-D-galactosamine 6-phosphate + H2O

D-galactosamine 6-phosphate + acetate

Escherichia coli

P0AF18

-

678301

-

-

?

N-acetyl-D-galactosamine-6-phosphate + H2O

D-galactosamine 6-phosphate + acetate

2 entries

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

32 entries

N-acetyl-D-glucosamine 6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

4 entries

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

8 entries

N-acetyl-D-glucosamine-6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

3 entries

N-acetyl-D-mannosamine-6-phosphate + H2O

D-mannosamine 6-phosphate + acetate

2 entries

N-acetylglucosamine + H2O

D-glucosamine + acetate

4 entries

N-formyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + formate

Escherichia coli

P0AF18

-

678301

-

-

?

N-thioacetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + thioacetate

Escherichia coli

P0AF18

-

678301

-

-

?

N-trifluoroacetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + trifluoroacetate

Escherichia coli

P0AF18

-

678301

-

-

?

additional information

?

-

6 entries

D-glucosamine 6-phosphate + acetate

N-acetyl-D-glucosamine 6-phosphate + H2O

Escherichia coli

-

-

246597

-

246597

r

D-glucosamine 6-phosphate + acetate

N-acetyl-D-glucosamine 6-phosphate + H2O

Escherichia coli overproducing

-

-

246597

-

246597

r

N-acetyl-D-galactosamine-6-phosphate + H2O

D-galactosamine 6-phosphate + acetate

Mycobacterium marinum

A0A3E2N0G4

very low activity

754179

-

-

?

N-acetyl-D-galactosamine-6-phosphate + H2O

D-galactosamine 6-phosphate + acetate

Mycolicibacterium smegmatis

A0A8B4QF55

low activity

754179

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Alteromonas sp.

-

-

246600

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Bacillus subtilis

-

-

246594

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Bifidobacterium bifidum

-

-

246594

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Bos taurus

-

-

246594

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

-

246590

-

246590

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

-

246591

-

246591

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

-

246593, 710931

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

enzyme of the N-acetylglucosamine pathway

246590

-

246590

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

enzyme of the N-acetylglucosamine pathway

246591

-

246591

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans

-

inducible enzyme, trichodermin and lomofungin inhibit induction of the enzyme

246591

-

246591

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Candida albicans BWP17

-

-

710931

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

-

-

246596, 669051, 669096, 712288

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

-

-

246592, 246594

-

-

ir

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

-

-

246597

-

-

r

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

P0AF18

-

669882, 678301

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

-

-

678301

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

-

enzyme is involved in aminosugar catabolism

246596

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

P0AF18

step in amino sugar catabolism

669882

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli JW0662

-

-

712288

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli overproducing

-

-

246597

-

-

r

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Homo sapiens

-

-

246598, 246599

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Homo sapiens

-

pathway of N-acetylglucosamine metabolism

246598

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Komagataeibacter xylinus

D2KKE6

-

720819

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Komagataeibacter xylinus 10245

D2KKE6

-

720819

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Listeria monocytogenes

Q8Y5F6, Q8Y8E8

-

718709

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Plasmodium falciparum

-

-

246598

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Plasmodium falciparum

-

pathway of N-acetylglucosamine metabolism

246598

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Rattus norvegicus

-

-

246589

-

246589

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Rattus norvegicus

-

-

246599

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Rattus norvegicus

-

presence of high deacetylase activity in endothelial cells and Kupffer cells but a virtual lack of activity in hepatocytes, suggests that the major part of the N-acetylglucosamine generated by the catabolism of glycoconjugates in the latter cells is reused in the synthesis of new complex carbohydrate molecules

246599

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Vibrio cholerae serotype O1

-

-

246595, 246600

-

-

?

N-acetyl-D-glucosamine 6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Vibrio cholerae serotype O1 Non-O1

-

-

246595

-

-

?

N-acetyl-D-glucosamine 6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Alteromonas sp.

-

-

246600

-

-

?

N-acetyl-D-glucosamine 6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Escherichia coli

P0AF18

-

678301

-

-

?

N-acetyl-D-glucosamine 6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Vibrio cholerae serotype O1

-

-

246595, 246600

-

-

?

N-acetyl-D-glucosamine 6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Vibrio cholerae serotype O1 Non-O1

-

-

246595

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Escherichia coli

P0AF18

-

678302

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Mycobacterium marinum

A0A3E2N0G4

-

754179

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Mycobacterium marinum

A0A3E2N0G4

preferred substrate

754179

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Mycolicibacterium smegmatis

A0A8B4QF55

-

754179

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Mycolicibacterium smegmatis

A0A8B4QF55

preferred substrate, structure of the GlcNAc6P substrate-binding site in MSNagA, overview

754179

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Staphylococcus aureus

-

-

753578

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Staphylococcus aureus USA300_TCH1516

-

-

753578

-

-

?

N-acetyl-D-glucosamine-6-phosphate + H2O

D-glucosamine 6-phosphate + acetate

Thermotoga maritima

-

-

678302

-

-

?

N-acetyl-D-glucosamine-6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Mycobacterium marinum

A0A3E2N0G4

-

754179

-

-

?

N-acetyl-D-glucosamine-6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Mycobacterium marinum

A0A3E2N0G4

low activity

754179

-

-

?

N-acetyl-D-glucosamine-6-sulfate + H2O

D-glucosamine 6-sulfate + acetate

Mycolicibacterium smegmatis

A0A8B4QF55

-

754179

-

-

?

N-acetyl-D-mannosamine-6-phosphate + H2O

D-mannosamine 6-phosphate + acetate

Mycobacterium marinum

A0A3E2N0G4

low activity

754179

-

-

?

N-acetyl-D-mannosamine-6-phosphate + H2O

D-mannosamine 6-phosphate + acetate

Mycolicibacterium smegmatis

A0A8B4QF55

low activity

754179

-

-

?

N-acetylglucosamine + H2O

D-glucosamine + acetate

Alteromonas sp.

-

-

246600

-

-

?

N-acetylglucosamine + H2O

D-glucosamine + acetate

Vibrio cholerae serotype O1

-

-

246595

-

246595

?

N-acetylglucosamine + H2O

D-glucosamine + acetate

Vibrio cholerae serotype O1

-

-

246600

-

-

?

N-acetylglucosamine + H2O

D-glucosamine + acetate

Vibrio cholerae serotype O1 Non-O1

-

-

246595

-

246595

?

additional information

?

-

Mycobacterium marinum

A0A3E2N0G4

no catalytic activity toward GlcNAc, GlcNGc6P, and MurNAc6P

754179

-

-

?

additional information

?

-

Mycobacterium marinum

-

no catalytic activity toward GlcNAc, GlcNGc6P, and MurNAc6P

754179

-

-

?

additional information

?

-

Mycolicibacterium smegmatis

A0A8B4QF55

no catalytic activity toward N-acetyl-D-glucosamine

754179

-

-

?

additional information

?

-

Mycolicibacterium smegmatis

-

no catalytic activity toward N-acetyl-D-glucosamine

754179

-

-

?

additional information

?

-

Staphylococcus aureus

-

performance of a coupled assay with NagB (EC 3.5.99.6) resulting in production of fructose 6-phosphate and NH3

753578

-

-

?

additional information

?

-

Staphylococcus aureus USA300_TCH1516

-

performance of a coupled assay with NagB (EC 3.5.99.6) resulting in production of fructose 6-phosphate and NH3

753578

-

-

?