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3.5.1.23: ceramidase

This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.

Word Map on EC 3.5.1.23

Reaction

a ceramide
+
H2O
=
a carboxylate
 +
sphingosine

Synonyms

(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.23 ceramidase

pH Range

pH Range on EC 3.5.1.23 - ceramidase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 7
activity range of neutral CDase, profile overview
3.5 - 4.6
-
-
4 - 10
5 - 11
5 - 8
-
very low ceramide synthesis activity below pH 5 or above pH 8
5 - 9.5
-
activity range
5.5 - 10
-
broad pH-range, ceramidase activity
5.7 - 6
-
-
6 - 7.5
maCER1 has a slight activity in the range
6 - 9
6.5 - 10.5
maCER1 has a negligible activity at pH lower than 6.5 or higher than 10.5
8 - 9
112 kDa CDase from kidney, 50% of activity in the range
9.5 - 10
maCER1 has a slight activity in the range
additional information
-
NlnCDase enzyme has a broad pH range for its activity