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3.5.1.23: ceramidase

This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.

Word Map on EC 3.5.1.23

Reaction

a ceramide
+
H2O
=
a carboxylate
 +
sphingosine

Synonyms

(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.23 ceramidase

Specific Activity

Specific Activity on EC 3.5.1.23 - ceramidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000000053
-
homozygous F508del mice, lung
0.000000055
-
wild-type mice, lung
0.000000056
-
heterozygous F508del mice, lung
0.000002
0.0000028
-
homozygous F508del mice, spleen
0.0000035
-
wild-type mice, lung
0.00000375
-
heterozygous F508del mice, lung
0.00000416
-
homozygous F508del mice, lung
0.00001
-
homozygous F508del mice, mucosal homogenates
0.0000127
-
heterozygous F508del mice, mucosal homogenates
0.0000137
-
heterozygous F508del mice, mucosal homogenates
0.0000145
-
homozygous F508del mice, mucosal homogenates
0.0000155
-
wild-type mice, mucosal homogenates
0.0000163
-
wild-type mice, mucosal homogenates
0.0000167
-
wild-type mice, mucosal homogenates
0.0000187
-
wild-type mice, kidney
0.0000188
-
heterozygous F508del mice, mucosal homogenates
0.0000192
-
homozygous F508del mice, mucosal homogenates
0.0000193
-
homozygous F508del mice, kidney
0.00002
-
homozygous F508del mice, mucosal homogenates
0.0000208
0.0000215
-
wild-type mice, liver
0.0000227
-
heterozygous F508del mice, mucosal homogenates
0.000023
-
wild-type mice, mucosal homogenates
0.0000238
-
homozygous F508del mice, liver
0.0000255
-
heterozygous F508del mice, liver
0.0000272
-
heterozygous F508del mice, mucosal homogenates
0.0000273
-
wild-type mice, mucosal homogenates
0.0000292
-
homozygous F508del mice, mucosal homogenates
0.0000308
-
heterozygous F508del mice, mucosal homogenates
0.0000417
-
wild-type mice, mucosal homogenates
0.000048
-
wild-type mice, mucosal homogenates
0.0000542
-
homozygous F508del mice, mucosal homogenates
0.0000625
-
heterozygous F508del mice, mucosal homogenates
0.0001
-
heterozygous F508del mice, mucosal homogenates
0.00032
mutant H97A/H99A
0.00052
control w1118 fly
0.00086
mutant Y448A
0.00125
CDase null mutant and CDase null expressing fat body driven CDase
0.00198
mutant H99A
0.00228
mutant R160A
0.00301
mutant H97A
0.00593
-
-
0.0081
-
-
0.00844
mutant H177A
0.00944
mutant R238A
0.0104
mutant Y560A
0.0129
wild type
0.0146
mutant Y460A
0.0338
-
pH 4.5, 37°C, recombinant AC expressed in CHO cells, hydrolysis of N-lauroylsphingosine
0.0387
mutant E411A
0.218
intracellular recombinant CDase expressed in Escherichia coli DH5alpha, pH 8.5, hydrolysis of N-palmitoyl sphingosine
0.239
extracellular wild-type CDase, pH 8.5, hydrolysis of N-palmitoyl sphingosine
1.1
-
non-purified enzyme, at pH 7.5 and 37°C
1.91
pH 7.5, 37°C, 112 kDa CDase from kidney, hydrolysis of 4-nitrobenzo-2-oxa-1,3-diazoyl-N-dodecanoylsphingosine
14.45
-
-
16720
-
after 15134fold purification, at pH 7.5 and 37°C
2.04
-
isoenzyme II
230.6
-
purified enzyme, pH 7.5, 37°C
3.647
-
-
5.72
-
isoenzyme I
additional information