3.5.1.23: ceramidase
This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.
Word Map on EC 3.5.1.23
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3.5.1.23
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adipor1
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sphingolipids
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obesity
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adipokine
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agonist
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sphingomyelinase
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sphingomyelin
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lysosomal
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farber
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obese
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leptin
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adipocytes
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amp-activated
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sphingosine-1-phosphate
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peroxisome
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cardiovascular
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proliferator-activated
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triglyceride
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globular
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insulin-sensitizing
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high-fat
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tnf
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smases
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adipocytokine
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adipocyte-derived
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monophosphate-activated
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anti-atherogenic
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t-cadherin
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steatosis
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adiposity
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glucosylceramide
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glycosphingolipids
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obesity-related
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antidiabetic
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1-phosphate
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seven-transmembrane
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gaucher
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dihydrosphingosine
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p-ampk
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palmitoyltransferase
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homa-ir
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sphingoid
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hoarseness
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ceramide-induced
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sphinganine
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ceramide-mediated
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dihydroceramide
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myoclonic
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adipocyte-secreted
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analysis
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pharmacology
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drug development
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medicine
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hypoadiponectinemia
- 3.5.1.23
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adipor1
- sphingolipids
- obesity
-
adipokine
- agonist
- sphingomyelinase
- sphingomyelin
- lysosomal
- farber
-
obese
- leptin
- adipocytes
-
amp-activated
- sphingosine-1-phosphate
- peroxisome
- cardiovascular
-
proliferator-activated
- triglyceride
-
globular
-
insulin-sensitizing
-
high-fat
- tnf
- smases
-
adipocytokine
-
adipocyte-derived
-
monophosphate-activated
-
anti-atherogenic
-
t-cadherin
- steatosis
-
adiposity
- glucosylceramide
- glycosphingolipids
-
obesity-related
-
antidiabetic
- 1-phosphate
-
seven-transmembrane
- gaucher
- dihydrosphingosine
-
p-ampk
- palmitoyltransferase
-
homa-ir
-
sphingoid
- hoarseness
-
ceramide-induced
- sphinganine
-
ceramide-mediated
- dihydroceramide
-
myoclonic
-
adipocyte-secreted
- analysis
- pharmacology
- drug development
- medicine
-
hypoadiponectinemia
Reaction
Synonyms
(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD
ECTree
3.5.1.23 ceramidaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.5.1.23 - ceramidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway
a significantly lower level of acid ceramidase expression was detected in gingival tissues from periodontal patients compared to those from healthy subjects
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skin squamous cell carcinoma cells, express very low levels of ACER3
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alkaline ceramidase activity and the generation of sphingosine and sphingosine-1-phosphate are increased during erythroid differentiation in K562 erythroleukemic cells, e.g. induced by chemotherapeutic agent cytosine arabinoside, Ara-C
SJGBM2-10y cell medium, which is rich in secreted ASAH1, promotes 50% more cell growth than SJGBM2 medium containing a lower level of secreted ASAH1
additional information
neutral ceramidase is highly expressed in colorectal tissues
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when the strain is cultured with sphingomyelin or phosphatidylcholine, production of the enzyme drastically increases, causing the increase of hemolytic activity in the cellfree culture supernatant. Ceramide and sphingosine are effective in promoting the production of ceramidase
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when the strain is cultured with sphingomyelin or phosphatidylcholine, production of the enzyme drastically increases, causing the increase of hemolytic activity in the cellfree culture supernatant. Ceramide and sphingosine are effective in promoting the production of ceramidase
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acid ceramidase is closely associated with malignant progression in human prostate cancer tissues. Acid ceramidase upregulation generates tumor cells that are resistant to normal homeostatic control mechanisms, have an increased number of metastatic characteristics and exhibit resistance to chemotherapy
differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis, distribution of acid and alkaline isozymes, overview
in rat hepatocytes, neutral CDase signals appear as many foci distributed throughout the cytoplasm partially co-localizing with the LPG85 signal, a marker for lysosomes/late endosomes
a strong signal for neutral CDase is detected in zebrafish intestine at the luminal surface of the villi and microvilli of adsorptive epithelial cells
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neutral ceramidase is expressed in the intestine and released in the intestinal lumen
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neutral ceramidase activities both in the intestinal mucosa and content are reduced by bile diversion. The presence of bile salts is important for maintaining high intraluminal levels of neutral ceramidase
differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
Ca2+ markedly upregulates the human acid ceramidase. Its upregulation mediates the Ca2+-induced growth arrest and differentiation of human epidermal keratinocytes by sphingosine and sphingosine phosphate
Ca2+ markedly upregulates the human alkaline ceramidase 1. Its upregulation mediates the Ca2+-induced growth arrest and differentiation of human epidermal keratinocytes by sphingosine and sphingosine phosphate
high CDase expression, enzyme is mainly localized at the apical membrane of proximal tubules, distal tubules and collecting ducts, enzyme is enriched in the raft microdomains with cholesterol and GM1 ganglioside
high expression level of neutral ceramidase, at the top of themicrovilli in proximal tubule cells
low CDase expression, enzyme is distributed with late endosomes/lysosomes in hepatocytes
human melanoma biopsies reveal heterogeneous staining of ASAH1 and low ASAH1 expression at the melanoma invasive front. ASAH1 is highly expressed and active in about 60% of melanoma cells, and its expression correlates with that of MITF
the enzyme is localized in the nuclei of H295R adrenocortical cells
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acid ceramidase is an essential component of the in vivo oocyte and embryo environment, it is expressed in the cortex and membrane at all stages of human oocyte maturation, expression analysis, overview
high enzyme level, increased expression of acid ceramidase in highly metastatic clones derived from PC-3 prostate cancer cells. The highly aggressive and metastatic PC-3/Mc cells display levels of acid ceramidase activity that are 2.5 to 4times higher than those of PC-3/S cells
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acid ceramidase is closely associated with malignant progression in human prostate cancer tissues. Acid ceramidase upregulation generates tumor cells that are resistant to normal homeostatic control mechanisms, have an increased number of metastatic characteristics and exhibit resistance to chemotherapy
highest expression level of neutral ceramidase, on the epithelial mucosa in the jejunum and ileum, neutral CDase is highly expressed in the small intestine along the brush border
additional information
tissue localization study, expression analysis, overview
additional information
isozyme tissue distribution, alkaline isozyme 1 is active for epidermis, small intestine, and thymus, all other isozymes are abundant, overview
additional information
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quantitation of acid ceramidase mRNA, overview, little ceramidase protein or activity, or sphingosine, in monocytes
additional information
acid ceramidase is abnormally expressed in various types of human cancer (e.g., prostate, head and neck, and colon) and serum enzyme levels are elevated in melanoma patients relative to control subjects
additional information
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acid ceramidase is abnormally expressed in various types of human cancer (e.g., prostate, head and neck, and colon) and serum enzyme levels are elevated in melanoma patients relative to control subjects
additional information
neutral ceramidase is ubiquitously expressed in various mammalian tissues
additional information
the nCDase subtype is a ubiquitously expressed enzyme
additional information
no significant fluctuation is detected for neutral or alkaline ceramidases in either gingival samples or cell cultures
additional information
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no significant fluctuation is detected for neutral or alkaline ceramidases in either gingival samples or cell cultures
additional information
very low expression of maCER1 in organs and tissues other than skin
additional information
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very low expression of maCER1 in organs and tissues other than skin
additional information
neutral ceramidase is ubiquitously expressed in various mammalian tissues
additional information
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the NlnCDase has higher transcript level and activity in adults than in eggs and nymphs, and in the reproductive organs (ovaries and spermaries) than in other tissues (i.e. heads, thorax, legs, midguts)
additional information
neutral ceramidase is ubiquitously expressed in various mammalian tissues
