3.5.1.23: ceramidase
This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.
Word Map on EC 3.5.1.23
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3.5.1.23
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adipor1
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sphingolipids
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obesity
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adipokine
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agonist
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sphingomyelinase
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sphingomyelin
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lysosomal
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farber
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obese
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leptin
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adipocytes
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amp-activated
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sphingosine-1-phosphate
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peroxisome
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cardiovascular
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proliferator-activated
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triglyceride
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globular
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insulin-sensitizing
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high-fat
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tnf
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smases
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adipocytokine
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adipocyte-derived
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monophosphate-activated
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anti-atherogenic
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t-cadherin
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steatosis
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adiposity
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glucosylceramide
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glycosphingolipids
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obesity-related
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antidiabetic
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1-phosphate
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seven-transmembrane
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gaucher
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dihydrosphingosine
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p-ampk
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palmitoyltransferase
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homa-ir
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sphingoid
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hoarseness
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ceramide-induced
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sphinganine
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ceramide-mediated
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dihydroceramide
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myoclonic
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adipocyte-secreted
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analysis
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pharmacology
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drug development
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medicine
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hypoadiponectinemia
- 3.5.1.23
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adipor1
- sphingolipids
- obesity
-
adipokine
- agonist
- sphingomyelinase
- sphingomyelin
- lysosomal
- farber
-
obese
- leptin
- adipocytes
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amp-activated
- sphingosine-1-phosphate
- peroxisome
- cardiovascular
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proliferator-activated
- triglyceride
-
globular
-
insulin-sensitizing
-
high-fat
- tnf
- smases
-
adipocytokine
-
adipocyte-derived
-
monophosphate-activated
-
anti-atherogenic
-
t-cadherin
- steatosis
-
adiposity
- glucosylceramide
- glycosphingolipids
-
obesity-related
-
antidiabetic
- 1-phosphate
-
seven-transmembrane
- gaucher
- dihydrosphingosine
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p-ampk
- palmitoyltransferase
-
homa-ir
-
sphingoid
- hoarseness
-
ceramide-induced
- sphinganine
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ceramide-mediated
- dihydroceramide
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myoclonic
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adipocyte-secreted
- analysis
- pharmacology
- drug development
- medicine
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hypoadiponectinemia
Reaction
Synonyms
(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD
ECTree
3.5.1.23 ceramidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.5.1.23 - ceramidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-erythro-C24:1-ceramide + H2O
C24:1 fatty acid + D-erythro-sphingosine
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?
D-erythro-tetracosanoyl-sphingosine + H2O
tetracosanoate + sphingosine
i.e. D-e-C24:0-ceramide
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?
N-acyl-sphingosine + H2O
a carboxylate + sphingosine
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the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the cellular levels of bioactive sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, in the intestinal tract
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-
?
ceramide + H2O
sphingosine + a fatty acid
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sphongosine is an apoptosis mediator
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?
ceramide + H2O
sphingosine + fatty acid
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-
-
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?
ceramide + H2O
sphingosine + fatty acid
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for ceramide clearance, ceramidases hydrolyze the N-acyl fatty acid, yielding in the generation of sphingosine
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-
?
ceramide + H2O
sphingosine + fatty acid
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-
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?
N-acylsphingosine + H2O
a carboxylate + sphingosine
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involved in the biosynthesis of ceramide, crucial enzyme for the regulation of the intracellular balance of the contents of ceramide, sphingosine and possibly sphingosine 1-phosphate
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-
?
N-acylsphingosine + H2O
a carboxylate + sphingosine
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involved in the biosynthesis of ceramide, crucial enzyme for the regulation of the intracellular balance of the contents of ceramide, sphingosine and possibly sphingosine 1-phosphate
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r
N-acylsphingosine + H2O
carboxylate + sphingosine
the carboxylate is a fatty acid
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-
?
N-acylsphingosine + H2O
carboxylate + sphingosine
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the carboxylate is a fatty acid
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-
?
N-acylsphingosine + H2O
carboxylate + sphingosine
the carboxylate is a fatty acid
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-
?
N-acylsphingosine + H2O
carboxylate + sphingosine
the carboxylate is a fatty acid
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-
?
N-acylsphingosine + H2O
carboxylate + sphingosine
the carboxylate is a fatty acid
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r
N-oleoyl-D-erythro-ceramide + H2O
oleate + D-erythro-sphingosine
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common substrate in erythrocytes
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?
N-oleoyl-D-erythro-ceramide + H2O
oleate + D-erythro-sphingosine
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common substrate in erythrocytes
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?
additional information
?
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-
ceramidase catalyzes the hydrolysis of ceramide to form sphingosine
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-
?
additional information
?
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ceramidases are a group of enzymes that catalyze the hydrolysis of ceramides to generate sphingosine, which is phosphorylated to form sphingosine 1-phosphate
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-
?
additional information
?
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ceramidases are a group of enzymes that catalyze the hydrolysis of ceramides to generate sphingosine, which is phosphorylated to form sphingosine 1-phosphate
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?
additional information
?
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ceramidases are a group of enzymes that catalyze the hydrolysis of ceramides to generate sphingosine, which is phosphorylated to form sphingosine 1-phosphate
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?
additional information
?
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critical role of AC in the regulation of sphingolipid metabolism
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?
additional information
?
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acidic and alkaline isozyme activities increase with keratinocyte differentiation, while the activities of phytoalkaline and neutral isozymes decrease, overview
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?
additional information
?
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CER2 catalyzes the hydrolysis of ceramides derived from both the de novo and sphingomyelin breakdown pathways, Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and sphingosine 1-phosphate
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?
additional information
?
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CER2 catalyzes the hydrolysis of ceramides derived from both the de novo and sphingomyelin breakdown pathways, Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and sphingosine 1-phosphate
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?
additional information
?
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cooperative prosurvival activity by MAP kinases ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity, overview, blocking of acid ceramidase but not sphingosine kinase activity in alveolar macrophages leads to decreased ERK and Akt activity and induction of cell death, sphingosine and L-threo-dihydrosphingosine reverse the antisurvival effects of acid ceramidase inhibition in alveolar macrophages
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?
additional information
?
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acid ceramidase plays a critical role in the regulation of ceramide and sphingosine metabolism
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?
additional information
?
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ASAH1 hydrolyzes ceramides and regulates neuronal development, and its deficiency often results in mental retardation. Results of linkage disequilibrium and polymorphism analyses suggest that a particular group of haplotypes in ASAH1 represents a signature of recent positive Darwinian selection
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?
additional information
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neutral ceramidase plays a major role in ceramide metabolism in the human gut
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?
additional information
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acid ceramidase deacylates ceramide and yields sphingosine
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?
additional information
?
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ceramidase catalyzes the hydrolysis of ceramide into sphingosine and a free fatty acid
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?
additional information
?
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ceramidase catalyzes the hydrolysis of ceramide to form sphingosine
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?
additional information
?
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ACER3 can catalyze the hydrolysis of unsaturated long-chain dihydroceramides as efficiently as unsaturated long-chain ceramides. ACER1 and ACER2, the homologues of ACER3, also catalyzed the hydrolysis of certain dihydroceramide species to generate dihydrosphingosine
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?
additional information
?
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only the natural D-erythro-ceramide isomer is used as substrate of the four stereoisomers of ceramide. Dihydroceramide or phytoceramide forms, shortening the length of the alkyl backbone, methylation of the primary or secondary hydroxyl groups results in reduction or loss of the neutral ceramidase activity
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-
?
additional information
?
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only the natural D-erythro-ceramide isomer is used as substrate of the four stereoisomers of ceramide. Dihydroceramide or phytoceramide forms, shortening the length of the alkyl backbone, methylation of the primary or secondary hydroxyl groups results in reduction or loss of the neutral ceramidase activity
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-
?
additional information
?
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only the natural D-erythro-ceramide isomer is used as substrate of the four stereoisomers of ceramide. Dihydroceramide or phytoceramide forms, shortening the length of the alkyl backbone, methylation of the primary or secondary hydroxyl groups results in reduction or loss of the neutral ceramidase activity
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-
?
additional information
?
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only the natural D-erythro-ceramide isomer is used as substrate of the four stereoisomers of ceramide. Dihydroceramide or phytoceramide forms, shortening the length of the alkyl backbone, methylation of the primary or secondary hydroxyl groups results in reduction or loss of the neutral ceramidase activity
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?
additional information
?
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short acyl-chain ceramides (i.e. C16 acyl chain) are poor substrates for acid ceramidase
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?
additional information
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short acyl-chain ceramides (i.e. C16 acyl chain) are poor substrates for acid ceramidase
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?
additional information
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short acyl-chain ceramides (i.e. C16 acyl chain) are poor substrates for acid ceramidase
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?
additional information
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short acyl-chain ceramides (i.e. C16 acyl chain) are poor substrates for acid ceramidase
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?
additional information
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acid ceramidase catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid
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?
additional information
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the N-acyl moiety of ceramide is cleaved by ceramidases to form the lysolipid sphingosine that undergoes further phosphorylation to sphingosine-1-phosphate
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?
additional information
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maCER1 may play a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-phosphate, as well as complex sphingolipids, maCER1 may have a specific role in skin function
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?
additional information
?
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maCER1 may play a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-phosphate, as well as complex sphingolipids, maCER1 may have a specific role in skin function
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?
additional information
?
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acid ceramidase, but not acid sphingomyelinase, is required for tumor necrosis factor-alpha-induced prostaglandin PGE2 production, overview
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?
additional information
?
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the enzyme is involved in ceramide metabolism at the plasma membrane and in extracellular milieu, hydrolysis of ceramide on the cell surface, overview, involvement of the enzyme in stimulus-induced Cer metabolism by doxorubicin
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?
additional information
?
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the enzyme is involved in degradation of epidermal ceramides, ceramidase activity is not age-dependent
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?
additional information
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ceramidase catalyzes the hydrolysis of ceramide to form sphingosine and free fatty acid
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?
additional information
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cleaves the N-acyl linkage of ceramides into a sphingosine base and a free fatty acid
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?
additional information
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the N-acyl moiety of ceramide is cleaved by ceramidases to form the lysolipid sphingosine that undergoes further phosphorylation to sphingosine-1-phosphate
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?
additional information
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CDase may be a virulence factor
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?
additional information
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ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa
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?
additional information
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ceramidase enhances cytotoxicity induced by hemolytic phospholipase C
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?
additional information
?
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ceramidase catalyzes the hydrolysis of ceramide to generate sphingosine and fatty acid, also found to catalyze the reverse reaction
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?
additional information
?
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ceramidase catalyzes the hydrolysis of ceramide to generate sphingosine and fatty acid, also found to catalyze the reverse reaction
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?
additional information
?
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the Pseudomonas neutral CDase can hydrolyze ceramide in intact erythrocytes, leading to hemolysis. The reaction mechanism for ceramide hydrolysis in vivo appears to be the same as that for ceramide hydrolysis in vitro because the mutation of residues surrounding the catabolic zinc ion abolish the hemolytic activity along with ceramide hydrolysis by CDase in intact erythrocytes
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?
additional information
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ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa
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?
additional information
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ceramidase enhances cytotoxicity induced by hemolytic phospholipase C
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?
additional information
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neutral ceramidase is involved in the regulation of ceramide-mediated signaling
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?
additional information
?
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the enzyme is important in digestion of sphingolipids
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?
additional information
?
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neutral ceramidase is a key enzyme for hydrolysis of sphingomyelin in the gut
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?
additional information
?
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ceramidase catalyzes the hydrolysis of ceramide to generate sphingosine and fatty acid, also found to catalyze the reverse reaction
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?
additional information
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ceramidase deacylates ceramide to form sphingosine
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?
