3.5.1.23: ceramidase
This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.
Word Map on EC 3.5.1.23
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3.5.1.23
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adipor1
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sphingolipids
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obesity
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adipokine
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agonist
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sphingomyelinase
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sphingomyelin
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lysosomal
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farber
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obese
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leptin
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adipocytes
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amp-activated
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sphingosine-1-phosphate
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peroxisome
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cardiovascular
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proliferator-activated
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triglyceride
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globular
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insulin-sensitizing
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high-fat
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tnf
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smases
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adipocytokine
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adipocyte-derived
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monophosphate-activated
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anti-atherogenic
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t-cadherin
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steatosis
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adiposity
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glucosylceramide
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glycosphingolipids
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obesity-related
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antidiabetic
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1-phosphate
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seven-transmembrane
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gaucher
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dihydrosphingosine
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p-ampk
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palmitoyltransferase
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homa-ir
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sphingoid
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hoarseness
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ceramide-induced
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sphinganine
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ceramide-mediated
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dihydroceramide
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myoclonic
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adipocyte-secreted
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analysis
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pharmacology
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drug development
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medicine
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hypoadiponectinemia
- 3.5.1.23
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adipor1
- sphingolipids
- obesity
-
adipokine
- agonist
- sphingomyelinase
- sphingomyelin
- lysosomal
- farber
-
obese
- leptin
- adipocytes
-
amp-activated
- sphingosine-1-phosphate
- peroxisome
- cardiovascular
-
proliferator-activated
- triglyceride
-
globular
-
insulin-sensitizing
-
high-fat
- tnf
- smases
-
adipocytokine
-
adipocyte-derived
-
monophosphate-activated
-
anti-atherogenic
-
t-cadherin
- steatosis
-
adiposity
- glucosylceramide
- glycosphingolipids
-
obesity-related
-
antidiabetic
- 1-phosphate
-
seven-transmembrane
- gaucher
- dihydrosphingosine
-
p-ampk
- palmitoyltransferase
-
homa-ir
-
sphingoid
- hoarseness
-
ceramide-induced
- sphinganine
-
ceramide-mediated
- dihydroceramide
-
myoclonic
-
adipocyte-secreted
- analysis
- pharmacology
- drug development
- medicine
-
hypoadiponectinemia
Reaction
Synonyms
(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD
ECTree
3.5.1.23 ceramidaseAdvanced search results
results (
results (Localization
Localization on EC 3.5.1.23 - ceramidase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
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ACER2 has 7 putative transmembrane domains, ACER2 membrane topology, overview. The N-terminal tail is necessary for both ACER2 activity and Golgi localization
inactive recombinant CDase expressed in Escherichia coli BL21 without its signal peptide
recombinant CDase expressed in Escherichia coli DH5alpha is most likely present in periplasm
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additional information
the enzyme localizes predominantly to the endoplasmic reticulum, and partially to the Golgi complex
maCER1 is localized to the endoplasmic reticulum and contains a Golgi to ER retrieval signal sequence
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113 kDa developing form, enzyme which is truncated at the C-terminus by four amino acids is retained in the endoplasmic reticulum and rapidly degraded without transportation to the Golgi apparatus
Myc-tagged CDase expressed in HEK-239 cells, a 113 kDa endoplasmic reticulum-form matures into a 133 kDa CDase during processing in the Golgi apparatus
a rat neutral CDase-GFP chimera protein, with GFP fused to the COOH terminus of the enzyme, is distributed in the ER/Golgi compartments and the plasma membrane of HEK293 cells
the N- and C-terminal ends of Ypc1p are oriented towards the lumen and cytosol, respectively, cytosolic or lumenal loops
CDase is distributed with late endosomes/lysosomes in hepatocytes
the neutral ceramidase is exclusively secreted into the medium through a vesicular transport system when expressed in S2 cells
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the majority of the recombinant AC overexpressed in CHO cells is secreted into the culture media
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wild-type CDase from 3-L culture, recombinant CDase expressed in Pseudomonas putida KT2440 and Pichia pastoris GS115
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the enzyme localizes predominantly to the endoplasmic reticulum, and partially to the Golgi complex
Myc-tagged CDase expressed in HEK-239 cells, a 113 kDa endoplasmic reticulum-form matures into a 133 kDa CDase during processing in the Golgi apparatus
a rat neutral CDase-GFP chimera protein, with GFP fused to the COOH terminus of the enzyme, is distributed in the ER/Golgi compartments and the plasma membrane of HEK293 cells
recombinant CDase expressed in Escherichia coli DH5alpha and BL21
CDase is distributed with late endosomes/lysosomes in hepatocytes
the neutral ceramidase is membrane-bound, enzyme membrane topology, overview
the neutral ceramidase is membrane-bound, enzyme membrane topology, overview
ACER3 is an intramembrane enzyme with a seven transmembrane domain architecture
the neutral ceramidase is membrane-bound, enzyme membrane topology, overview
membrane-bound, 112 kDa-form, mainly localized at the apical membrane of proximal tubules, distal tubules and collecting ducts of kidney, microsome, sequence contains one possible transmembrane domain
membrane topology of rat neutral CDase, overview. A rat neutral CDase-GFP chimera protein, with GFP fused to the COOH terminus of the enzyme, is distributed in the ER/Golgi compartments and the plasma membrane of HEK293 cells
kidney, microsomal fraction contains a large amount of membrane-bound 112 kDa neutral CDase
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type II integral protein with its N-terminal end anchored to the plasma membrane and C-terminal end exposed to the extracellular space
a rat neutral CDase-GFP chimera protein, with GFP fused to the COOH terminus of the enzyme, is distributed in the ER/Golgi compartments and the plasma membrane of HEK293 cells. The CDase is transported to the plasma membrane through the classical ER/Golgi pathway
additional information
subcellular localization study, expression analysis, overview
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additional information
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ACER2 C- and N-termini are oriented in the lumen of the Golgi complex and cytosol, respectively
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additional information
determination and analysis of subcellular localization of wild-type and recombinantly overexpressed immunostained nCDase
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additional information
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the enzyme has a putative signal peptide of 25 residues at the N-terminal
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additional information
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subcellular localization of wild-type and several C-terminal truncated CDases
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additional information
the cell-surface expression of CDase is strongly inhibited by brefeldin A or treatment at 5°C, neutral and alkaline enzyme membrane topology, overview
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