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3.5.1.23: ceramidase

This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.

Word Map on EC 3.5.1.23

Reaction

a ceramide
+
H2O
=
a carboxylate
 +
sphingosine

Synonyms

(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.23 ceramidase

Expression

Expression on EC 3.5.1.23 - ceramidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
A-375 cells are induced by doxycycline to overexpress the enzyme
acid ceramidase expression in gingival cells is suppressed by stimulation with Porphyromonas gingivalis in vitro
acid ceramidase is overexpressed in most prostate tumors
-
acid ceramidase protein and mRNA are decreased during egg aging
-
ACTH/cAMP signaling stimulates acid ceramidase ASAH1 transcription and activity
ACTH/cAMP signaling stimulates the enzyme transcription and activity
gemcitabine downregulates the neutral ceramidase
infection with the rice strip virus or treatment with insecticides significantly increase LsnCer mRNA expression and its enzymatic activity in Laodelphax striatellus, quantitative real time PCR enzyme expression analysis
interleukin-1beta increases the activity, mRNA levels and protein synthesis of acid ceramidase
interleukin-1beta increases the activity, mRNA levels and protein synthesis of neutral ceramidase
ionizing radiation selectively upregulates acid ceramidase in prostate cancer PCa cells, no induction of neutral and alkaline ceraamidases. Radiation-induced acid ceramidase gene transactivation by activator protein 1 binding on the proximal promoter is sensitive to inhibition of de novo ceramide biosynthesis, as demonstrated by promoter reporter and ChIP-qPCR analyses
irradiation induces expression of ASAH1 in glioblastoma multiforme cells, radiation induces oversecretion of ASAH1
isoform ACER2 is upregulated in tumors
mRNA levels are higher in the adult stage than in pre-adult stages
-
radiation-induced acid ceramidase upregulation confers resistance to taxane
-
significantly decreased ceramide levels are observed in human colon cancers, gliomas, ovarian cancers, thyroid and gastrointestinal cancers
-
the microphthalmia-associated transcription factor (MITF) drives expression of ASAH1. MITF is a transcription factor that binds to DNA to control the expression of its targets. MITF stimulates the activity of ASAH1 promoter
the prominent antiestrogen tamoxifen is a pan-effective acid ceramidase inhibitor in the low micromolar range, as demonstrated in a wide spectrum of cancer cell types, prostate, pancreatic, colorectal, and breast. Tamoxifen does not impact cell viability or inhibit the enzyme activity in cell-free assays. Mechanism of action via increases in lysosomal membrane permeability, and time- and dose-dependent downregulation of acid ceramidase protein expression, overview. The downregulation can be blocked by a cathepsin B inhibitor
the retinoid N-(4-hydroxyphenyl)retinamide, i.e. fenretinide, increases the expression of ACER-2 through a retinoic acid receptor-independent and caspase-dependent manner
-
transcripts and activity of the NlnCDase are upregulated under abiotic stresses including starvation, abnormal temperature, and insecticides, and biotic stress of resistant rice varieties
-
treatment with fetal bovine serum (FBS) induces approximately a 60% increase in nCDase mRNA expression in coronary artery smooth muscle cells after 6 h. FBS elevates nCDase mRNA expression approximately 35% in HEK-293. cells c-Jun/AP-1 signaling in part regulates serum-induced human nCDase gene transcription
-