3.5.1.23: ceramidase
This is an abbreviated version!
For detailed information about ceramidase, go to the full flat file.
Word Map on EC 3.5.1.23
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3.5.1.23
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adipor1
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sphingolipids
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obesity
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adipokine
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agonist
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sphingomyelinase
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sphingomyelin
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lysosomal
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farber
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obese
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leptin
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adipocytes
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amp-activated
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sphingosine-1-phosphate
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peroxisome
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cardiovascular
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proliferator-activated
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triglyceride
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globular
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insulin-sensitizing
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high-fat
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tnf
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smases
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adipocytokine
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adipocyte-derived
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monophosphate-activated
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anti-atherogenic
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t-cadherin
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steatosis
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adiposity
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glucosylceramide
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glycosphingolipids
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obesity-related
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antidiabetic
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1-phosphate
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seven-transmembrane
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gaucher
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dihydrosphingosine
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p-ampk
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palmitoyltransferase
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homa-ir
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sphingoid
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hoarseness
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ceramide-induced
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sphinganine
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ceramide-mediated
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dihydroceramide
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myoclonic
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adipocyte-secreted
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analysis
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pharmacology
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drug development
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medicine
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hypoadiponectinemia
- 3.5.1.23
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adipor1
- sphingolipids
- obesity
-
adipokine
- agonist
- sphingomyelinase
- sphingomyelin
- lysosomal
- farber
-
obese
- leptin
- adipocytes
-
amp-activated
- sphingosine-1-phosphate
- peroxisome
- cardiovascular
-
proliferator-activated
- triglyceride
-
globular
-
insulin-sensitizing
-
high-fat
- tnf
- smases
-
adipocytokine
-
adipocyte-derived
-
monophosphate-activated
-
anti-atherogenic
-
t-cadherin
- steatosis
-
adiposity
- glucosylceramide
- glycosphingolipids
-
obesity-related
-
antidiabetic
- 1-phosphate
-
seven-transmembrane
- gaucher
- dihydrosphingosine
-
p-ampk
- palmitoyltransferase
-
homa-ir
-
sphingoid
- hoarseness
-
ceramide-induced
- sphinganine
-
ceramide-mediated
- dihydroceramide
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myoclonic
-
adipocyte-secreted
- analysis
- pharmacology
- drug development
- medicine
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hypoadiponectinemia
Reaction
Synonyms
(dihydro)ceramidase, AC, aCDase, ACER, ACER type 3, ACER-2, ACER1, ACER2, ACER3, acid ceramidase, acylsphingosine deacylase, adiponectin receptor, ADIPOR2, alkaline ceramidase, alkaline ceramidase 1, alkaline ceramidase 2, alkaline ceramidase 3, alkCDase, alkCDase-1, alkCDase-2, ASAH-1, ASAH1, asah1b, ASAH2, ASAH2B, ASAH3, AsahA, AtACER, AtNCER1, bwa, CBCDase, CDase, CDase II, CER2, ceramidase, Dacer, Drosophila alkaline ceramidase, glycosphingolipid ceramide deacylase, Golgi alkaline ceramidase, haCER1, intramembrane ceramidase, LsnCer, maCER1, mt-CDase, N-acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase 2, N-acylsphingosine amidohydrolase-1, N-acylsphingosine aminohydrolase, N-acylsphingosine deacylase, N-CDase, nCDase, ncer1, neutral CDase, neutral ceramidase, neutral ceramidase 2, NlnCDase, OsCDase, PaCD, PaCDase, pan-ceramidase, PHP32, phytoalkaline ceramidase, phytoCDase, Putative 32 KDA heart protein, SCDase, sphingolipid ceramide N-deacylase, Tncer, TOD1, turgor regulation defect 1, Ydc1p, yeast dihydroceramidase 1, yeast phyto-ceramidase 1, Ypc1p, znCD
ECTree
3.5.1.23 ceramidaseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.5.1.23 - ceramidase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate
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a bile salt analog
adiponectin
activates the ceramidase activity of adiponectin receptor ADIPOR2 about 20fold. Adiponectin is a hormone, secreted mainly from adipocytes, that stimulates glucose utilization and fatty-acid oxidation
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all-trans retinoic acid
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all-trans retinoic acid, ATRA, increases the expression of ACER2 in HeLa cells
cAMP-responsive element binding protein
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CREB is a central regulator os ASAH1 gene transcription
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cytokine
a cytokine mixture of interleukin-1beta, tumor necrose factor-alpha and interferon-gamma is used
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Detergents
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required for activity, e.g. NP-40, sodium cholate, Triton X-100, or Tween-20
N-(4-hydroxyphenyl)retinamide
increases isoform ACER2 activity and mRNA, but not isoforms ACER1 or ACER3
saposin-D
a hydrophobic surface surrounding the substrate binding channel appears to be a site of membrane attachment where the enzyme accepts substrates facilitated by the accessory protein, saposin-D
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cardiolipin
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phosphatidylglycerol and cardiolipin, which are major lipid components of Staphylococcus aureus, are effective in stimulating the hydrolysis of human skin-type ceramides in the absence of detergents
cardiolipin
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activates the ceramidase activity by 2.5fold at 8-10 mol%, inhibits the ceramide synthesis activity, mechanism
phosphatidylglycerol
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phosphatidylglycerol and cardiolipin, which are major lipid components of Staphylococcus aureus, are effective in stimulating the hydrolysis of human skin-type ceramides in the absence of detergents
sodium cholate
112 kDa CDase from kidney, optimum concentration: 0.4-2%, 4-5fold activation
sodium taurodeoxycholate
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activates the recombinant enzyme about 2fold, optimally at 1%
sodium taurodeoxycholate
112 kDa CDase from kidney, optimum concentration: 0.1-0.2%, 4-5fold activation
Triton X-100
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activates the recombinant enzyme about 2fold, optimally at 0.05%
Triton X-100
2fold activation at 0.1-0.2%, but inhibitory beyond the optimum concentration
additional information
phosphatidylethanolamine and phosphatidylcholine have little effect on the activity regardless of the concentration
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additional information
Bac-Dacer microsomes cause a twofold increase in ceramidase activity on D-e-C6, D-e-C12, D-e-C16, D-e-C18, and D-e-C24:1-ceramide at pH 9.0
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additional information
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Bac-Dacer microsomes cause a twofold increase in ceramidase activity on D-e-C6, D-e-C12, D-e-C16, D-e-C18, and D-e-C24:1-ceramide at pH 9.0
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additional information
serum deprivation up-regulates both haCER2 mRNA and activity in recombinant HeLa cells, haCER2mRNA is also up-regulated in some tumors
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additional information
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serum deprivation up-regulates both haCER2 mRNA and activity in recombinant HeLa cells, haCER2mRNA is also up-regulated in some tumors
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additional information
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acid ceramidase requires anionic lysosomal lipids and saposin as cofactors for efficient hydrolysis of ceramide in vivo
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additional information
acid ceramidase requires anionic lysosomal lipids and saposin as cofactors for efficient hydrolysis of ceramide in vivo
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additional information
acid ceramidase requires anionic lysosomal lipids and saposin as cofactors for efficient hydrolysis of ceramide in vivo
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additional information
acid ceramidase requires anionic lysosomal lipids and saposin as cofactors for efficient hydrolysis of ceramide in vivo
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additional information
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ACTH/cAMP signaling stimulates the enzyme transcription and activity
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additional information
ACTH/cAMP signaling stimulates the enzyme transcription and activity
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additional information
infection with the rice strip virus or treatment with insecticides significantly increase LsnCer mRNA expression and its enzymatic activity in Laodelphax striatellus
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additional information
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infection with the rice strip virus or treatment with insecticides significantly increase LsnCer mRNA expression and its enzymatic activity in Laodelphax striatellus
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