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3.5.1.2: glutaminase

This is an abbreviated version!
For detailed information about glutaminase, go to the full flat file.

Word Map on EC 3.5.1.2

Reaction

L-glutamine
+
H2O
=
L-glutamate
+
NH3

Synonyms

AnsB, AoGls, GA, GAB, GAC, GahB, GLA, GLNase, GLS, GLS1, GLS2, GlsA, glutaminase, glutaminase 1, glutaminase 2, glutaminase A, glutaminase B, glutaminase C, glutaminase I, glutaminase K, glutaminase L, glutaminase-1, glutaminase-2, glutaminase-B, glutamine amidohydrolase, glutamine aminohydrolase, glutamine deamidating enzyme, K-glutaminase, KAG, KGA, kidney-type glutaminase, kidney-type-glutaminase, L-glutaminase, L-glutamine amidohydrolase, LAG, LGA, liver-type glitaminase, liver-type glutaminase, Mglu, Micrococcus glutaminase Mglu, Micrococcus luteus K-3-type glutaminase, mitochondrial glutaminase, N-PAG, neuroblastoma glutaminase, neuroblastoma PAG, Nit 2, nitrilase 2, omega-amidase, PAG, PDX2, phosphate activated glutaminase, phosphate-activated glutaminase, phosphate-activated L-glutamine amidohydrolase, salt-tolerant glutaminase, YaaE

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.2 glutaminase

Expression

Expression on EC 3.5.1.2 - glutaminase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation
-
GLS2 expression is reduced in liver tumors
-
is induced in response to DNA damage or oxidative stress in a p53-dependent manner, and p53 associates with the GLS promotor
-
isoforms GAB and KGA protein expression levels are higher in human hepatoma HepG2 and lung carcinoma A549 cells than those in fibroblast cell lines Detroit 551 and WI-38, whilst isoform GAC expression levels are not significantly changed
-
maximal production of both enzymes is observed at 37°C, pH 5.0 and 96 h incubation time in solid state fermentation with wheat bran
p53 increases the GLS2 expression under both nonstressed and stressed conditions
-
wild-type TrpG shows no constitutive activity and needs to be induced by TrpE
-