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3.5.1.14: N-acyl-aliphatic-L-amino acid amidohydrolase

This is an abbreviated version!
For detailed information about N-acyl-aliphatic-L-amino acid amidohydrolase, go to the full flat file.

Word Map on EC 3.5.1.14

Reaction

an N-acetyl-L-cysteine-S-conjugate
+
H2O
=
an L-cysteine-S-conjugate
+
acetate

Synonyms

AA1, AA3, AAIII, ACY 1a, ACY 1b, ACY-1, ACY-1A, Acy1, acylase, acylase 1, acylase B, acylase I, alpha-N-acylaminoacid hydrolase, amido acid deacylase, aminoacylase, aminoacylase 1, aminoacylase 1a, aminoacylase 3, aminoacylase I, aminoacylase-1, aminoacylase-1A, aminoacylase-1B, benzamidase, D-AAse, D-Aminoacylase, dehydropeptidase II, DR_ACY, fatty acid-amino acid conjugate hydrolyzing aminoacylase 1, fMDF, fungus aminoacylase-1, hAcy1, hippurase, hippuricase, histozyme, HKA, hog intestinal acylase I, hog kidney aminoacylase, hog kidney aminoacylase I, intestine acylase I, L-ACY-1, L-amido-acid acylase, L-aminoacylase, LAA, lepidopteran aminoacylase 1, long acyl amidoacylase, M20, More, N-Acyl-D-aspartate amidohydrolase, N-acyl-L-amino acid amidohydrolase, N-acyl-L-amino acid hydrolase, N-acyl-L-amino-acid amidohydrolase, N-acyl-L-aminoacylase 1, N-acylase IA, N-formylmethionine deformylase, Nalpha-acyl-L-amino acid amidohydrolase, pAcy1, PhoACY, pig kidney aminoacylase, porcine kidney aminoacylase, short acyl amidoacylase, sphingosine kinase 1-interacting protein

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase

General Stability

General Stability on EC 3.5.1.14 - N-acyl-aliphatic-L-amino acid amidohydrolase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
Co2+ activates and stabilizes
-
relatively stable, urea causes marked activation of the immobilized enzyme, immobilized enzyme resistant against denaturation by guanidinium hydrochloride
-
very active and physically stable, resistant to urea, 85% activity retained with 8 M urea at 37°C for 30 min
-
Zn2+, 1 mM or 10 mM, enhances thermostability
-