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3.5.1.13: aryl-acylamidase

This is an abbreviated version!
For detailed information about aryl-acylamidase, go to the full flat file.

Word Map on EC 3.5.1.13

Reaction

an anilide
+
H2O
=
a carboxylate
+
aniline

Synonyms

AAA, aryl acylamidase, aryl acylaminidase, Azl13, EC 3.5.1.13 AAA-2, EC 3.5.1.13, AAA-1, M-1 amidase, More, PamH, polyamidase, pseudocholinesterase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.13 aryl-acylamidase

Substrates Products

Substrates Products on EC 3.5.1.13 - aryl-acylamidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2',3'-dichloropropionanilide + H2O
2,3-dichloroaniline + propionate
show the reaction diagram
-
14% of the activity with 3',4'-dichloropropionanilide
-
-
?
2',4'-dichloropropionanilide + H2O
2,4-dichloroaniline + propionate
show the reaction diagram
-
49% of the activity with 3',4'-dichloropropionanilide
-
-
?
2',6'-dimethylacetanilide + H2O
?
show the reaction diagram
2'-chloropropionanilide + H2O
2-chloroaniline + propionate
show the reaction diagram
-
37% of the activity with 3',4'-dichloropropionanilide
-
-
?
2,5-dimethylfuran-3-carboxanilide + H2O
?
show the reaction diagram
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
show the reaction diagram
2-nitrotrifluoroacetanilide + H2O
2-nitroaniline + trifluoroacetic acid
show the reaction diagram
acetylcholinesterase exhibits two different activities: esterase and aryl acylamidase
-
-
?
3',4'-dichloro-2-methacrylanilide + H2O
3,4-dichloroaniline + 2-methyl-2-propenoate
show the reaction diagram
-
8% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichloroacetanilide + H2O
3,4-dichloroaniline + acetate
show the reaction diagram
-
49% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichlorobutyranilide + H2O
3,4-dichloroaniline + butyrate
show the reaction diagram
-
37% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
show the reaction diagram
3',4'-dichlorovaleranilide + H2O
3,4-dichloroaniline + pentanoate
show the reaction diagram
-
12% of the activity with 3',4'-dichloropropionanilide
-
-
?
3'-chloropropionanilide + H2O
3-chloroaniline + propionate
show the reaction diagram
-
51% of the activity with 3',4'-dichloropropionanilide
-
-
?
3,4-dichloropropionanilide + H2O
?
show the reaction diagram
-
plants with significant amounts of aryl acylamidase are able to hydrolyze acylanilide herbicides quickly and thereby avoid the toxic effects of these compounds
-
-
?
3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea + H2O
3,4-dichloroaniline + ?
show the reaction diagram
-
i.e. linuron
-
?
3-(acetamido)N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetic acid
show the reaction diagram
-
-
-
-
?
4'-chloropropionanilide + H2O
4-chloroaniline + propionate
show the reaction diagram
-
54% of the activity with 3',4'-dichloropropionanilide
-
-
?
4-acetamidophenol + H2O
acetate + 4-aminophenol
show the reaction diagram
4-acetylaminobenzaldehyde thiosemicarbazone + H2O
4-aminobenzaldehyde thiosemicarbazone + acetic acid
show the reaction diagram
-
i.e. thiacetazone
-
?
4-chloroacetanilide + H2O
acetate + 4-chloroaniline
show the reaction diagram
-
-
-
r
4-nitroacetanilide + H2O
4-nitroaniline + acetate
show the reaction diagram
4-nitroacetanilide + H2O
acetate + 4-nitroaniline
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
acetamide + H2O
acetic acid + NH3
show the reaction diagram
-
-
-
-
?
acetaminophen + H2O
4-aminophenol + acetate
show the reaction diagram
-
i.e. paracetamol
-
?
acetanilide + H2O
acetate + aniline
show the reaction diagram
adipic acid bishexylamide + H2O
adipic acid + dihexylamine
show the reaction diagram
-
-
-
-
?
Ala-NH2 + H2O
Ala + NH3
show the reaction diagram
-
-
-
-
?
Asp-p-nitroanilide + H2O
Asp + p-nitroaniline
show the reaction diagram
-
-
-
-
?
asparagine + H2O
aspartic acid + NH3
show the reaction diagram
-
-
-
-
?
benzamide + H2O
benzoate + NH3
show the reaction diagram
-
-
-
?
benzamide + H2O
benzoic acid + NH3
show the reaction diagram
-
-
-
-
?
butyramide + H2O
butanoic acid + NH3
show the reaction diagram
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly 2-naphthylamine
show the reaction diagram
Gly-p-nitroanilide + H2O
Gly + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Phe-NH2 + H2O
Gly-Phe + NH3
show the reaction diagram
-
-
-
-
?
Gly-Pro-Leu-p-nitroanilide + H2O
Gly-Pro-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
hexanoamide + ?
hexanoic acid + NH3
show the reaction diagram
-
-
-
-
?
hydroxyacetanilide + H2O
hydroxyaniline + acetate
show the reaction diagram
-
-
-
-
?
L-Ala beta-naphthylamide + H2O
Ala + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
Ala + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Arg beta-naphthylamide + H2O
Arg + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Glu-beta-naphthylamide + H2O
Glu + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Leu beta-naphthylamide + H2O
Leu + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Leu p-nitroanilide + H2O
Leu + p-nitroaniline
show the reaction diagram
L-Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Leu-L-Ala + H2O
Leu + Ala
show the reaction diagram
-
-
-
-
?
L-Leu-L-Phe + H2O
Leu + Phe
show the reaction diagram
-
-
-
-
?
L-Leu-L-Tyr + H2O
Leu + Tyr
show the reaction diagram
-
-
-
-
?
L-Leu-L-Val + H2O
Leu + Val
show the reaction diagram
-
-
-
-
?
L-Lys beta-naphthylamide + H2O
Lys + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Met beta-naphthylamide + H2O
Met + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
Leu-Gly-NH2 + H2O
Leu-Gly + NH3
show the reaction diagram
-
-
-
-
?
Leu-NH2 + H2O
Leu + NH3
show the reaction diagram
-
-
-
-
?
mandelamine + H2O
mandelic acid + NH3
show the reaction diagram
-
-
-
-
?
methacrylamide + H2O
methacrylic acid + NH3
show the reaction diagram
-
-
-
-
?
N-(2,4-dinitrophenyl)acetamide + H2O
N-(2,4-dinitrophenyl)aniline + acetate
show the reaction diagram
-
-
-
-
?
N-(2-nitrophenyl)-trifluoroacetamide + H2O
2-nitroaniline + trifluoroacetic acid
show the reaction diagram
N-(2-nitrophenyl)acetamide + H2O
N-(2-nitrophenyl)aniline + acetate
show the reaction diagram
N-(2-nitrophenyl)benzamide + H2O
N-(2-nitrophenyl)aniline + benzoic acid
show the reaction diagram
-
no activity with acetylcholinesterase
-
-
?
N-(2-nitrophenyl)butanamide + H2O
N-(2-nitrophenyl)aniline + butyrate
show the reaction diagram
N-(2-nitrophenyl)heptanamide + H2O
N-(2-nitrophenyl)aniline + heptanoate
show the reaction diagram
-
-
-
-
?
N-(2-nitrophenyl)hexanacetamide + H2O
N-(2-nitrophenyl)aniline + hexanoate
show the reaction diagram
N-(2-nitrophenyl)octanamide + H2O
N-(2-nitrophenyl)aniline + octanoate
show the reaction diagram
-
-
-
-
?
N-(2-nitrophenyl)pentanacetamide + H2O
N-(2-nitrophenyl)aniline + pentanoate
show the reaction diagram
N-(2-nitrophenyl)phenylacetamide + H2O
N-(2-nitrophenyl)aniline + phenylacetate
show the reaction diagram
-
-
-
-
?
N-(2-nitrophenyl)propanamide + H2O
N-(2-nitrophenyl)aniline + propionate
show the reaction diagram
N-(2-nitrophenyl)trifluoroacetamide + H2O
N-(2-nitrophenyl)aniline + trifluoroacetate
show the reaction diagram
N-(3,4-dichlorophenyl) propanamide + H2O
3,4-dichloroaniline + propanoic acid
show the reaction diagram
i.e. propanil
-
-
?
N-(3,4-dichlorophenyl)propanamide + H2O
3,4-dichloraniline + propanoate
show the reaction diagram
no activity with butachlor, acetochlor, 4-nitroacetanilide, p-chloracetanilide
-
-
?
N-(3-methoxy-2-nitrophenyl)acetamide + H2O
N-(3-methoxy-2-nitrophenyl)aniline + acetate
show the reaction diagram
N-(3-nitrophenyl)acetamide + H2O
N-(3-nitrophenyl)aniline + acetate
show the reaction diagram
-
-
-
-
?
N-(4-nitrophenyl)acetamide + H2O
N-(4-nitrophenyl)aniline + acetate
show the reaction diagram
-
-
-
-
?
N-(5-methoxy-2-nitrophenyl)acetamide + H2O
N-(5-methoxy-2-nitrophenyl)aniline + acetate
show the reaction diagram
N-(o-nitrophenyl)trifluoroacetamide + ?
2-nitroaniline + trifluoracetic acid
show the reaction diagram
-
aryl acylamidase activity of fatty acid-free human serum albumin
-
-
?
N-phenylacetamide + H2O
N-phenylaniline + acetate
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-Arg beta-naphthylamide + H2O
Nalpha-benzoyl-DL-Arg + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
nicotinamide + H2O
nicotinic acid + NH3
show the reaction diagram
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
show the reaction diagram
o-nitroacetanilide + H2O
2-nitroaniline + acetic acid
show the reaction diagram
o-nitroacetanilide + H2O
o-nitroaniline + acetate
show the reaction diagram
-
-
-
-
?
o-nitrotrifluoroacetanilide + H2O
o-nitroaniline + trifluoroacetic acid
show the reaction diagram
-
reaction is performed by human serum albumin, substrate is more reactive than o-nitroacetanilide
-
-
?
p-acetotoluidide + H2O
?
show the reaction diagram
p-nitroacetanilide + H2O
4-nitroaniline + acetate
show the reaction diagram
p-nitroacetanilide + H2O
4-nitroaniline + acetic acid
show the reaction diagram
-
-
-
-
?
p-nitroacetanilide + H2O
p-nitroaniline + acetate
show the reaction diagram
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
-
-
-
-
r
Phe-NH2 + H2O
Phe + NH3
show the reaction diagram
-
-
-
-
?
phenacetin + H2O
acetate + 4-ethoxyaniline
show the reaction diagram
Pro-NH2 + H2O
Pro + NH3
show the reaction diagram
-
-
-
-
?
propanamide + H2O
propanoic acid + NH3
show the reaction diagram
-
-
-
?
propionamide + H2O
propanoic acid + NH3
show the reaction diagram
-
-
-
-
?
stearamide + H2O
stearic acid + NH3
show the reaction diagram
-
-
-
-
?
Val-beta-naphthylamide + H2O
Val + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
additional information
?
-