3.5.1.13: aryl-acylamidase
This is an abbreviated version!
For detailed information about aryl-acylamidase, go to the full flat file.
Word Map on EC 3.5.1.13
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3.5.1.13
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acetylcholinesterase
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aaa
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cholinesterases
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o-nitroacetanilide
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buche
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acetanilid
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eserine
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serotonin-sensitive
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propanil
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3.1.1.8
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neostigmine
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pharmacology
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acylanilide
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diagnostics
- 3.5.1.13
- acetylcholinesterase
- aaa
- cholinesterases
- o-nitroacetanilide
- buche
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acetanilid
- eserine
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serotonin-sensitive
- propanil
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3.1.1.8
- neostigmine
- pharmacology
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acylanilide
- diagnostics
Reaction
Synonyms
AAA, aryl acylamidase, aryl acylaminidase, Azl13, EC 3.5.1.13 AAA-2, EC 3.5.1.13, AAA-1, M-1 amidase, More, PamH, polyamidase, pseudocholinesterase
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Natural Substrates Products
Natural Substrates Products on EC 3.5.1.13 - aryl-acylamidase
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REACTION DIAGRAM
3,4-dichloropropionanilide + H2O
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plants with significant amounts of aryl acylamidase are able to hydrolyze acylanilide herbicides quickly and thereby avoid the toxic effects of these compounds
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4-acetamidophenol + H2O
acetate + 4-aminophenol
i.e. Tylenol
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induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
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induction by 2',6'-dimethylacetanilide
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induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
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induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
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induction by 2',6'-dimethylacetanilide
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additional information
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induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
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additional information
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induction by 2',6'-dimethylacetanilide
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additional information
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induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
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the aryl amide activity of the acetylcholinesterase has a distinct role in embryogenesis
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the aryl acylamidase activity, especially of butyrylcholinesterase, is involved in the development of the nervous system and in pathological processes such as the formation of neuritic plaques in Alzheimer's disease
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the reaction in human erythrocytes and plasma is performed by the butyrylcholinesterase, EC 3.1.1.8, which is inactive with butyrylthiocholine, also fatty acid free human albumin has aryl acylacylamidase activity, which accounts for 10% of total human enzyme activity
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inducible by various phenylamides of the acylanilide, phenylcarbamate, and methoxysubstituted phenylurea type
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induced by anilide, not subject to carbon or nitrogen repression by the growth medium
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4-guanidinobutyramide probably is the natural substrate
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4-guanidinobutyramide probably is the natural substrate
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key enzyme in plant herbicide detoxification
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