3.5.1.121: protein N-terminal asparagine amidohydrolase
This is an abbreviated version!
For detailed information about protein N-terminal asparagine amidohydrolase, go to the full flat file.
Word Map on EC 3.5.1.121
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3.5.1.121
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deamidation
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asparagine-specific
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e3alpha
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outwardly
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r2r3-myb
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lashley
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glutamine-specific
- 3.5.1.121
-
deamidation
-
asparagine-specific
-
e3alpha
-
outwardly
-
r2r3-myb
-
lashley
-
glutamine-specific
Reaction
Synonyms
amidohydrolase for N-terminal asparagine, N-terminal amidase, N-terminal asparagine amidohydrolase, Nt-amidase, NTA1, NTAN1, NTAN1 amidase, NTAN1p amidase, NtN-amidase, PNAD, protein NH2-terminal asparagine deamidase, yNta1
ECTree
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Systematic Name
Systematic Name on EC 3.5.1.121 - protein N-terminal asparagine amidohydrolase
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protein N-terminal asparagine amidohydrolase
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.