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3.5.1.121: protein N-terminal asparagine amidohydrolase

This is an abbreviated version!
For detailed information about protein N-terminal asparagine amidohydrolase, go to the full flat file.

Word Map on EC 3.5.1.121

Reaction

N-terminal L-asparaginyl-[protein]
+
H2O
=
N-terminal L-aspartyl-[protein]
+
NH3

Synonyms

amidohydrolase for N-terminal asparagine, N-terminal amidase, N-terminal asparagine amidohydrolase, Nt-amidase, NTA1, NTAN1, NTAN1 amidase, NTAN1p amidase, NtN-amidase, PNAD, protein NH2-terminal asparagine deamidase, yNta1

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.121 protein N-terminal asparagine amidohydrolase

Systematic Name

Systematic Name on EC 3.5.1.121 - protein N-terminal asparagine amidohydrolase

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SYSTEMATIC NAME
IUBMB Comments
protein N-terminal asparagine amidohydrolase
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.