3.5.1.115: mycothiol S-conjugate amidase
This is an abbreviated version!
For detailed information about mycothiol S-conjugate amidase, go to the full flat file.
Word Map on EC 3.5.1.115
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3.5.1.115
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tuberculosis
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actinomycetes
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deacetylase
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glcnac-ins
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mycothiol-dependent
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electrophilic
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mercapturic
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smegmatis
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amide
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monobromobimane
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n-acetylcysteine
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metalloprotein
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antimycobacterial
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cerulenin
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rifamycin
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text
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sponge
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alpha-helices
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deacetylation
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bromotyrosine
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accys
-
medicine
- 3.5.1.115
- tuberculosis
- actinomycetes
- deacetylase
-
glcnac-ins
-
mycothiol-dependent
-
electrophilic
-
mercapturic
- smegmatis
- amide
- monobromobimane
- n-acetylcysteine
- metalloprotein
-
antimycobacterial
- cerulenin
- rifamycin
-
text
-
sponge
-
alpha-helices
-
deacetylation
-
bromotyrosine
-
accys
- medicine
Reaction
Synonyms
MCA, mycothiol S-conjugate amidase, Rv1082
ECTree
3.5.1.115 mycothiol S-conjugate amidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.5.1.115 - mycothiol S-conjugate amidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
RifS13 + H2O
1-D-myo-inositol-alpha-D-glucopyranoside + N-acetyl-S-[(2R,12Z,14E,16S,18S,19S,20S,21S,22S,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-21-(methoxycarbonyl)-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-yl]-L-cysteine
-
-
-
-
?
RifS17 + H2O
1-D-myo-inositol-alpha-D-glucopyranoside + N-acetyl-S-[(2R,12Z,14E,16S,18S,19S,20S,21S,22S,23S,24E)-5,17,19-trihydroxy-23-methoxy-21-(methoxycarbonyl)-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-yl]-L-cysteine
-
-
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
-
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
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the enzyme is extremely specific for the mycothiol portion of the mycothiol S-conjugate and relatively nonspecific with respect to the R-moiety
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
the enzyme is extremely specific for the mycothiol portion of the mycothiol S-conjugate and relatively nonspecific with respect to the R-moiety
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-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
-
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
the enzyme is extremely specific for the mycothiol portion of the mycothiol S-conjugate and relatively nonspecific with respect to the conjugate moiety
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
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the enzyme is highly specific for S-conjugates of mycothiol
-
-
?
a mycothiol S-conjugate + H2O
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
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-
-
-
?
mycothiol bimane + H2O
mycothiol + bimane
-
-
-
?
mycothiol-3-(N-maleimidopropionyl)biocytin + H2O
?
-
-
-
-
?
mycothiol-3-(N-maleimidopropionyl)biocytin + H2O
?
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5.2% activity compared to mycothiol bimane derivative
-
-
?
mycothiol-7-(diethylamino)-3-(4'-maleimidylphenyl)-4-methylcoumarin + H2O
?
-
-
-
-
?
mycothiol-7-(diethylamino)-3-(4'-maleimidylphenyl)-4-methylcoumarin + H2O
?
-
-
-
-
?
mycothiol-7-(diethylamino)-3-(4'-maleimidylphenyl)-4-methylcoumarin + H2O
?
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3.8% activity compared to mycothiol bimane derivative
-
-
?
mycothiol-cerulenin + H2O
?
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8% activity compared to mycothiol bimane derivative
-
-
?
mycothiol-monobromobimane + H2O
? + 1D-myo-inosityl 2-amino-2-deoxy-glucopyranoside
-
-
-
-
?
mycothiol-monobromobimane + H2O
? + 1D-myo-inosityl 2-amino-2-deoxy-glucopyranoside
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
-
-
-
?
mycothiol-N-ethylmaleimide + H2O
?
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2.1% activity compared to mycothiol bimane derivative
-
-
?
additional information
?
-
the wild-type enzyme is active on a mycothiol S-conjugate of monobromobimane (MSmB) in vivo
-
-
?
additional information
?
-
-
the wild-type enzyme is active on a mycothiol S-conjugate of monobromobimane (MSmB) in vivo
-
-
?
additional information
?
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substrate specificity, overview. The enzyme also deacetylates N-acetyl-D-glucosamine
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-
?
additional information
?
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-
substrate specificity, overview. The enzyme also deacetylates N-acetyl-D-glucosamine
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-
?
additional information
?
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the wild-type enzyme is active on a mycothiol S-conjugate of monobromobimane (MSmB) in vivo
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-
?
additional information
?
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substrate specificity, overview. The enzyme also deacetylates N-acetyl-D-glucosamine
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-
?
additional information
?
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the enzyme is highly specific for the mycothiol moiety of mycothiol S-conjugates and relatively nonspecific for the structure of the sulfur-linked conjugate
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-
?
additional information
?
-
-
the enzyme is highly specific for the mycothiol moiety of mycothiol S-conjugates and relatively nonspecific for the structure of the sulfur-linked conjugate
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-
?
additional information
?
-
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the enzyme is nearly inactive with mycothiol, mycothiol disulfide, and Glc-NAc-Ins
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-
?
additional information
?
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-
no activity with mycothiol, mycothiol disulfide, 2-(N-acetyl-L-cysteinyl)amido-2-deoxy-(alpha,beta)-D-glucopyranoside monobromobiane derivate, and 1-D-myo-inosityl-2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside monobromobiane derivate
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-
?
