3.5.1.109: sphingomyelin deacylase
This is an abbreviated version!
For detailed information about sphingomyelin deacylase, go to the full flat file.
Word Map on EC 3.5.1.109
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3.5.1.109
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atopic
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dermatitis
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stratum
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corneum
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ceramidase
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sphingolipids
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glucosylsphingosine
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lysoforms
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uninvolved
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beta-glucocerebrosidase
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histamine
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acylceramide
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palmitic
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keratinocytes
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sphingomyelinase
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undiscovered
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barrier-disrupted
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5-lipoxygenase
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2-mercaptoethanol
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scratching
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naltrexone
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sphingosylphosphocholine
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leukotriene
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water-holding
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smase
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2d-sds-page
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nonlesional
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sphingosylphosphorylcholine-induced
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acdase
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intradermal
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spc-induced
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medicine
- 3.5.1.109
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atopic
- dermatitis
-
stratum
- corneum
- ceramidase
- sphingolipids
- glucosylsphingosine
-
lysoforms
-
uninvolved
- beta-glucocerebrosidase
- histamine
- acylceramide
-
palmitic
-
keratinocytes
- sphingomyelinase
-
undiscovered
-
barrier-disrupted
-
5-lipoxygenase
- 2-mercaptoethanol
-
scratching
- naltrexone
- sphingosylphosphocholine
-
leukotriene
-
water-holding
- smase
-
2d-sds-page
-
nonlesional
-
sphingosylphosphorylcholine-induced
- acdase
-
intradermal
-
spc-induced
- medicine
Reaction
Synonyms
GC deacylase, GcSM deacylase, glucosylceramide deacylase, glucosylceramide sphingomyelin deacylase, SM deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase, sphingomyelin glucosylceramide deacylase
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Source Tissue
Source Tissue on EC 3.5.1.109 - sphingomyelin deacylase
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in peripheral blood lymphocytes of patients with atopic dermatitis, there is no increase in activity compared with healthy controls
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in extracts of whole epidermis biopsies from patients with atopic dermatitis, sphingomyelin deacylase activities are significantly (3-fold) increased over healthy controls in the particulate fraction, whereas there is no significant difference in the activity of sphingomyelinase between atopic dermatitis and healthy control
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activity is enhanced more than 5fold in involved stratum corneum, more than 3fold in uninvolved stratum corneum, and approximately 3fold in the involved epidermis from patients with atopic dermatitis compared with healthy controls
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from lesional forearm skin (volar side) of patients with atopic dermatitis, sphingomyelin deacylase activity is at least 5times higher than in the stratum corneum of healthy controls. In stratum corneum from nonlesional skin of patients with atopic dermatitis, SM deacylase activity is at least three times higher than in healthy controls. Stratum corneum from contact dermatitis patients shows levels of sphingomyelin deacylase similar to healthy controls
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upregulation in stratum corneum of patients with atopic dermatitis