3.5.1.109: sphingomyelin deacylase

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For detailed information about sphingomyelin deacylase, go to the full flat file.

Word Map on EC 3.5.1.109

3.5.1.109

atopic

dermatitis

stratum

corneum

ceramidase

sphingolipids

glucosylsphingosine

lysoforms

uninvolved

beta-glucocerebrosidase

histamine

acylceramide

palmitic

keratinocytes

sphingomyelinase

undiscovered

barrier-disrupted

5-lipoxygenase

2-mercaptoethanol

scratching

naltrexone

sphingosylphosphocholine

leukotriene

water-holding

smase

2d-sds-page

nonlesional

sphingosylphosphorylcholine-induced

acdase

intradermal

spc-induced

medicine

Reaction

Synonyms

GC deacylase, GcSM deacylase, glucosylceramide deacylase, glucosylceramide sphingomyelin deacylase, SM deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase, sphingomyelin glucosylceramide deacylase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.109 sphingomyelin deacylase

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37	Disease/ Diagnostics
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Reference on EC 3.5.1.109 - sphingomyelin deacylase

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711127

Higuchi, K.; Hara, J.; Okamoto, R.; Kawashima, M.; Imokawa, G.

The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

Biochem. J.

350

747-756

2000

Homo sapiens

10970788

712591

Imokawa, G.

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

J. Dermatol. Sci.

1-9

2009

Homo sapiens

19443184

712668

Hara, J.; Higuchi, K.; Okamoto, R.; Kawashima, M.; Imokawa, G.

High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis

J. Invest. Dermatol.

115

406-413

2000

Homo sapiens

10951276

712912

Ishibashi, M.; Arikawa, J.; Okamoto, R.; Kawashima, M.; Takagi, Y.; Ohguchi, K.; Imokawa, G.

Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis

Lab. Invest.

397-408

2003

Homo sapiens

12649340