3.4.99.B2: D-aspartyl endopeptidase
This is an abbreviated version!
For detailed information about D-aspartyl endopeptidase, go to the full flat file.
Word Map on EC 3.4.99.B2
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3.4.99.B2
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alzheimer
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cataracts
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noxious
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d-aspartate
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misfolding
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proteasome
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aging-related
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arteriosclerosis
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lactacystin-sensitive
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multi-complex
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racemized
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prion
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paenibacillus
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d-isomers
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lactacystin
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elegans
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analysis
- 3.4.99.B2
- alzheimer
-
cataracts
-
noxious
- d-aspartate
-
misfolding
- proteasome
-
aging-related
-
arteriosclerosis
-
lactacystin-sensitive
-
multi-complex
-
racemized
- prion
- paenibacillus
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d-isomers
- lactacystin
- elegans
- analysis
Reaction
paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side =
Synonyms
D-aspartyl endopeptidase, DAEP, paenidase
ECTree
3.4.99.B2 D-aspartyl endopeptidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.99.B2 - D-aspartyl endopeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DAEFRH-(D-Asp)-GSY + H2O
DAEFRH-(D-Asp) + GSY
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synthetic Abeta peptide. No cleavage of the D-Aspcontaining Abeta peptide, paenidase I and II. Paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side
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?
L-Thr-L-Val-L-Leu-D-alpha-Asp-L-Ser-Gly-L-Ile-L-Ser-L-Glu-L-Val-L-Arg + H2O
?
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-
?
succinyl-D-Asp-alpha-4-methylcoumaryl-7-amide + H2O
succinyl-D-Asp + 7-amino-4-methylcoumarin
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-
-
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?
[D-Asp]AEFRH[D-Asp]SGY + H2O
[D-Asp]AEFRHX + SGY
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the D-Abeta1-10 peptide is degraded at D-Asp7 and two peptides are produced [D-Asp]AEFRHX and SGY. X is not identified in this study. L-Abeta110 peptide could not be degraded by this enzyme
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-
?
[D-Asp]AEFRH[D-Asp]SGY + H2O
[D-Asp]AEFRH[D-Asp] + SGY
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the D-Abeta1-10 peptide is degraded at D-Asp7 and two peptides are produced [D-Asp]AEFRHX and SGY. X is not identified in this study. L-Abeta110 peptide could not be degraded by this enzyme
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?
succinyl-D-Asp-4-methylcoumaryl-7-amide + H2O
succinyl-D-Asp + 7-amino-4-methylcoumarin
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-
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?
succinyl-D-Asp-4-methylcoumaryl-7-amide + H2O
succinyl-D-Asp + 7-amino-4-methylcoumarin
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paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side
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-
?
succinyl-D-Asp-7-amido-4-methylcoumarin + H2O
succinyl-D-Asp + 7-amino-4-methylcoumarin
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?
succinyl-D-Asp-7-amido-4-methylcoumarin + H2O
succinyl-D-Asp + 7-amino-4-methylcoumarin
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-
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?
succinyl-D-Asp-p-nitroanilide + H2O
succinyl-D-Asp + p-nitroaniline
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paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side
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?
succinyl-D-Asp-p-nitroanilide + H2O
succinyl-D-Asp + p-nitroaniline
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-
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?
additional information
?
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the enzyme may serve as a scavenger against accumulation of racemized proteins in aging
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?
additional information
?
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no activity with succinyl-L-Asp-7-amido-4-methylcoumarin, L-Thr-L-Val-L-Leu-L-alpha-Asp-L-Ser-Gly-L-Ile-L-Ser-L-Glu-L-Val-L-Arg, L-Thr-L-Val-L-Leu-D-beta-Asp-L-Ser-Gly-L-Ile-L-Ser-L-Glu-L-Val-L-Arg and L-Thr-L-Val-L-Leu-D-beta-Asp-L-Ser-Gly-L-Ile-L-Ser-L-Glu-L-Val-L-Arg
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-
?
additional information
?
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the accumulation of D-isomers of aspartic acid in proteins during aging is involved in the pathogenesis of Alzheimers disease, cataracts, and arteriosclerosis. The enzyme may serve as a scavenger against accumulation of racemized proteins in aging
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?
additional information
?
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the enzyme may serve as a scavenger against accumulation of racemized proteins in aging
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?
additional information
?
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no activity with acetyl-Tyr-Val-Ala-Asp-4-methylcoumaryl-7-amide, acetyl-Asp-Glu-Val-Asp-4-methylcoumaryl-7-amide, succinyl-Gly-Pro-Leu-Gly-Pro-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide, Leu-4-methylcoumaryl-7-amide, succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Leu-Leu-Glu-4-methylcoumaryl-7-amide, Ala-Ala-Phe-4-methylcoumaryl-7-amide, succinyl-Ala-[D-Ser]-4-methylcoumaryl-7-amide, succinyl-[D-Ser]-4-methylcoumaryl-7-amide
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?
additional information
?
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no activity with acetyl-Tyr-Val-Ala-Asp-4-methylcoumaryl-7-amide, acetyl-Asp-Glu-Val-Asp-4-methylcoumaryl-7-amide, succinyl-Gly-Pro-Leu-Gly-Pro-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide, Leu-4-methylcoumaryl-7-amide, succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide, benzyloxycarbonyl-Leu-Leu-Glu-4-methylcoumaryl-7-amide, Ala-Ala-Phe-4-methylcoumaryl-7-amide, succinyl-Ala-[D-Ser]-4-methylcoumaryl-7-amide, succinyl-[D-Ser]-4-methylcoumaryl-7-amide
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?
additional information
?
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no activity with: acetyl-L-Asp-p-nitroanilide, D-Asp-p-nitroanilide, A-Ala-p-nitroanilide, D-Leu-p-nitroanilide, D-Phe-p-nitroanilide, L-Asp-p-nitroanilide, L-Ala-p-nitroanilide, L-Leu-p-nitroanilide, L-Phe-p-nitroanilide, L-Arg-p-nitroanilide, L-Glu-p-nitroanilide, Gly-p-nitroanilide, L-His-p-nitroanilide, L-Ile-p-nitroanilide, L-Lys-p-nitroanilide, L-Met-p-nitroanilide, L-Pro-p-nitroanilide, L-Val-p-nitroanilide, p-nitroanilide, succinyl-L-Ala-L-Pro-L-Ala, succinyl-L-Ala-L-Ala-L-Ala-p-nitroanilide, L-Pyr-p-nitroanilide, Arg-4-methylcoumaryl-7-amide, benzoyl-Arg-4-methylcoumaryl-7-amide, tert-butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumaryl-7-amide, Pro-Phe-Arg-4-methylcoumaryl-7-amide, acetyl-Tyr-val-Ala-Asp-4-methylcoumaryl-7-amide, acetyl-ASp-GLu-Val-Asp-4-methylcoumaryl-7-amide, acetyl-Val-Glu-Ile-Asp-4-methylcoumaryl-7-amide
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?
additional information
?
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enzyme specifically recognizes an internal D-Asp residue to cleave [D-Asp]-X peptide bonds
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?
