3.4.99.B2: D-aspartyl endopeptidase
This is an abbreviated version!
For detailed information about D-aspartyl endopeptidase, go to the full flat file.
Word Map on EC 3.4.99.B2
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3.4.99.B2
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alzheimer
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cataracts
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noxious
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d-aspartate
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misfolding
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proteasome
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aging-related
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arteriosclerosis
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lactacystin-sensitive
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multi-complex
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racemized
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prion
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paenibacillus
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d-isomers
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lactacystin
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elegans
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analysis
- 3.4.99.B2
- alzheimer
-
cataracts
-
noxious
- d-aspartate
-
misfolding
- proteasome
-
aging-related
-
arteriosclerosis
-
lactacystin-sensitive
-
multi-complex
-
racemized
- prion
- paenibacillus
-
d-isomers
- lactacystin
- elegans
- analysis
Reaction
paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side =
Synonyms
D-aspartyl endopeptidase, DAEP, paenidase
ECTree
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Inhibitors
Inhibitors on EC 3.4.99.B2 - D-aspartyl endopeptidase
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benzoyl-Arg-His-D-Asp-CH2Cl
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1 mM, about 70% inhibition of paenidase I and II
Co2+
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1.0 mM, 31% inhibition of paenidase I, 46% inhibition of paenidase II
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1.0 mM MnCl2, 31% inhibition of paenidase I, 60% inhibition of paenidase II
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no inhibition: N-p-tosyl-L-phenylalanine chloromethyl ketone, N-p-tosyl-L-lysine chloromethyl ketone, phenylmethylsulfonyl fluoride, trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-alanyl-L-alanyl-L-phenylalanyl-chloromethane, chymostatin, EDTA, epoxomicin, N-acetyl-L-leucyl-L-leucyl-norleucinal
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additional information
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no inhibition: N-p-tosyl-L-phenylalanine chloromethyl ketone, N-p-tosyl-L-lysine chloromethyl ketone, phenylmethylsulfonyl fluoride, trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-alanyl-L-alanyl-L-phenylalanyl-chloromethane, chymostatin, EDTA
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additional information
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no inhibition: iodoacetic acid, p-chloromercuribenzoate, EDTA, 1,10-phenanthroline, amastatin, antipain, diisopropylfluorophosphate, soybean trypsin inhibitor
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