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3.4.99.B2: D-aspartyl endopeptidase

This is an abbreviated version!
For detailed information about D-aspartyl endopeptidase, go to the full flat file.

Word Map on EC 3.4.99.B2

Reaction

paenidases specifically recognize internal D-Asp residues and hydrolyze them on the COOH side =

Synonyms

D-aspartyl endopeptidase, DAEP, paenidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
                3.4.99.B2 D-aspartyl endopeptidase

Inhibitors

Inhibitors on EC 3.4.99.B2 - D-aspartyl endopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
0.1 mM, 8.3% inhibition
Aprotinin
-
0.1 mM, 14% inhibition
benzoyl-Arg-His-D-Asp-CH2Cl
-
1 mM, about 70% inhibition of paenidase I and II
benzoyl-Arg-His-[D-Asp]-CH2Cl
0.1 mM, 48% residual activity
benzoyl-L-Arg-L-His-D-Asp-CH2Cl
-
0.003 mM, 50% inhibition
biotinyl-(epsilon-aminocaproic acid)-L-Arg-L-His-D-Asp-CH2Cl
-
-
Co2+
-
1.0 mM, 31% inhibition of paenidase I, 46% inhibition of paenidase II
diisopropyl fluorophosphate
-
at 0.5 mM, 15.5% inhibition
lactacystin
leupeptin
-
0.03 mM, 8.5% inhibition
NEM
-
0.1 mM, about 10% inhibition
pepstatin
-
0.01 mg/ml, about 50% inhibition of paenidase I and II
pepstatin A
phosphoramidon
-
0.01 mM, 9.9% inhibition
additional information
-