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3.4.25.2: HslU-HslV peptidase

This is an abbreviated version!
For detailed information about HslU-HslV peptidase, go to the full flat file.

Word Map on EC 3.4.25.2

Reaction

ATP-dependent cleavage of peptide bonds with broad specificity. =

Synonyms

AAA+ HslUV protease, AAA+ protease HslUV, ATP-dependent protease, ATP-dependent protease hslV, ClpQ, ClpQY, ClpYQ, ClpYQ complex, ClpYQ protease, CodW, CodW-CodX, heat shock protein hslV, HslU ATPase, HslU chaperone, HslU/HslV, HslUV, HslUV complex, HslUV protease, HslUV protease-chaperone complex, HslV, HslV peptidase, HslV protease, HslV-HslU, hslVU, HslVU ATP-dependent protease, HslVU protease, LINF_150005800, PfHslUV, T01.006

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.2 HslU-HslV peptidase

Inhibitors

Inhibitors on EC 3.4.25.2 - HslU-HslV peptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,4-dichloroisocoumarin
-
0.2 mM, 50% inhibition
acety-Leu-Leu-norleucinal
-
0.01 mM, 90% inhibition
ADP
-
when added together with ATP
benzyloxycarbonyl-Ile-Glu(tert-butyl)-Ala-Leu-al
-
0.001 mM, almost complete inhibition of peptidase activity, no inhibition of hydrolysis of insulin B-chain or other polypeptide substrates
benzyloxycarbonyl-Leu-Leu-norleucinal
-
0.01 mM, 97% inhibition
benzyloxycarbonyl-Leu-Leu-norvalinal
-
0.004 mM, inhibits hydrolysis of both benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin and insulin B-chain to a similar extent
diisopropyl fluorophosphate
-
10 mM, about 70% inhibition
dithiothreitol
-
-
lactacystin
N-acetyl-Leu-Leu-norleucinal
-
i.e. calpain inhibitor-I, inhibits HslV
NLVS
-
in the presence of ATP, the proteasome inhibitor markedly increases the interaction between HslV and HslU and causes the activation of the HslU ATPase
phenylmethylsulfonyl fluoride
additional information
-