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3.4.25.1: proteasome endopeptidase complex

This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.1 proteasome endopeptidase complex

Substrates Products

Substrates Products on EC 3.4.25.1 - proteasome endopeptidase complex

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-aminocyclopropane-1-carboxylic acid synthase 6 + H2O
?
show the reaction diagram
-
phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase 6 introduces negative charges to the C-terminus of ACS6, which reduces the turnover of 1-aminocyclopropane-1-carboxylic acid synthase 6 by the 26S proteasome degradation machinery
-
-
?
4-hydroxy-3-nitrophenol-Leu-Leu-Asn-vinylsulfone + H2O
?
show the reaction diagram
-
-
?
4-hydroxy-3-nitrophenyl-Leu-Leu-Lys-vinylsulfone + H2O
?
show the reaction diagram
-
-
?
AAF-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
highest activity in testicle, kidney and brain
-
?
ABZ-Val-Val-Ser-Arg-Ser-Leu-Gly-Tyr(3-NO2)-NH2 + H2O
?
show the reaction diagram
-
synthetic, internally quenched substrate
-
-
?
acetyl-Ala-Pro-norleucine-Leu-Leu-7-amido-4-methylcoumarin + H2O
acetyl-Ala-Pro-norleucine-Leu-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-Arg-hSer-Thr-Arg-7-amido-4-methylcoumarin + H2O
acetyl-Arg-hSer-Thr-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate for trypsin-like activity
-
-
?
acetyl-betaAla-Met(sulfone)-Thr-Arg-7-amido-4-methylcoumarin + H2O
acetyl-betaAla-Met(sulfone)-Thr-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate for trypsin-like activity
-
-
?
acetyl-DPSD-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
cleaved by the beta1 subunit of the 20S proteasome
-
-
?
acetyl-EPFD-7-amido-4-carbamoylcoumarin + H2O
?
show the reaction diagram
acetyl-GPLD-7-amido-4-methylcoumarin + H2O
acetyl-GPLD + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-GPLE-7-amido-4-methylcoumarin + H2O
acetyl-GPLE + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-GPLL-7-amido-4-methylcoumarin + H2O
acetyl-GPLL + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-hArg-Pro-2-fluoro-Phe-Asp-7-amido-4-methylcoumarin + H2O
acetyl-hArg-Pro-2-fluoro-Phe-Asp + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate for caspase-like activity
-
-
?
acetyl-hArg-Pro-Abu-Asp-7-amido-4-methylcoumarin + H2O
acetyl-hArg-Pro-Abu-Asp + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate for caspase-like activity
-
-
?
acetyl-HHSL-7-amido-4-carbamoylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
acetyl-norleucine-Arg-norleucine-Arg-7-amido-4-carbamoylcoumarin + H2O
?
show the reaction diagram
acetyl-norleucine-Leu-Pro-norleucine-Leu-YVAD-7-amido-4-methylcoumarin + H2O
acetyl-norleucine-Leu-Pro-norleucine-Leu-YVAD + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-Phe-Thr(Bzl)-His(3-benzyloxymethyl)-Leu-7-amido-4-methylcoumarin + H2O
acetyl-Phe-Thr(Bzl)-His(3-benzyloxymethyl)-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate for chymotrypsin-like activity
-
-
?
acetyl-YVAD-7-amido-4-methylcoumarin + H2O
acetyl-YVAD + 7-amino-4-methylcoumarin
show the reaction diagram
acetyl-YWTQ-7-amido-4-carbamoylcoumarin + H2O
?
show the reaction diagram
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
Ala-Ala-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-LRR-4-methyl-7-amido-coumarin + H2O
benzoyl-LRR + 4-methyl-7-amino-coumarin
show the reaction diagram
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-VGR-4-methyl-7-amido-coumarin + H2O
benzoyl-VGR + 4-methyl-7-amino-coumarin
show the reaction diagram
-
trypsin-like proteasome activity
-
-
?
benzoyl-VGR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
benzyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Ala-Ala-Leu-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-ARR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-D-Ala-Leu-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-dALR-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-FR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GAPLG-p-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GGF-4-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-GGF-p-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GGL-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GGL-4-nitroanilide + H2O
?
show the reaction diagram
-
chymotrypsin-like activity
-
?
benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-GGL + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GGR-2-naphthylamide + H2O
?
show the reaction diagram
-
trypsin-like activity
-
?
benzyloxycarbonyl-GGR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
benzyloxycarbonyl-Gly-Gly-Arg-beta-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Leu-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Leu-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
benzyloxycarbonyl-Gly-Gly-Leu-p-nitroanilide + H2O
?
show the reaction diagram
benzyloxycarbonyl-Gly-Pro-Ala-Gly-Gly-p-aminobenzoate + aminopeptidase-N + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Ala-Leu-Ala-p-aminobenzoate + aminopeptidase-N + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-GPAFG-4-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-GPAFG-p-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GPAGG-4-aminobenzoate + H2O
?
show the reaction diagram
-
highest activity in soleus and brain
-
?
benzyloxycarbonyl-GPAGG-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-GPALG-4-aminobenzoate + H2O
?
show the reaction diagram
benzyloxycarbonyl-GPALG-p-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-LAF-4-aminobenzoate + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Leu-Leu-Glu-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
11% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
-
?
benzyloxycarbonyl-Leu-Leu-Glu-beta-naphthylamide + H2O
?
show the reaction diagram
benzyloxycarbonyl-Leu-Leu-Leu-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
36% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
-
?
benzyloxycarbonyl-LLE-2-naphthylamide + H2O
?
show the reaction diagram
benzyloxycarbonyl-LLE-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-LLE-beta-naphthylamide + H2O
?
show the reaction diagram
-
caspase-like activity
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-RR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
beta-casein + H2O
?
show the reaction diagram
-
-
-
-
?
Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
Boc-Leu-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Boc-Leu-Leu-Glu-4-methylcoumarin-7-amide + H2O
Boc-Leu-Leu-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O
Boc-Leu-Ser-Thr-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Bz-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Bz-DL-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Bz-VGR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
DBC2 protein + H2O
?
show the reaction diagram
-
-
-
-
?
dihydrofolate reductase + H2O
?
show the reaction diagram
ERM transcription factor + H2O
?
show the reaction diagram
-
-
-
-
?
erythroid Krueppel-like factor + H2O
?
show the reaction diagram
-
-
-
-
?
fructose-1,6-bisphosphatase + H2O
?
show the reaction diagram
-
-
-
-
?
Glu-Gly-Gly-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
H-VLK-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very-low activity
-
?
hepatitis B virus X protein + H2O
?
show the reaction diagram
-
-
-
-
?
IGF-1 + H2O
?
show the reaction diagram
-
-
-
-
?
IkappaBalpha + H2O
?
show the reaction diagram
-
can be directly degraded by 20S proteasomes. Deletion constructs of IkappaBalpha allow us to the determine that N-terminal (DELTA1-70)and C-terminal regions (DELTA280-327, removing the PEST region) of IkappaBalpha are not required for IkappaBalpha degradation,while a further C-terminal deletion including part of the arm repeats (DELTAC2 245-327) almost completely suppress the degradation by 20S proteasome. Degradation of IkappaBalpha involves specific interactions with a C3 subunit of the proteasome
-
-
?
Ile-Ile-Trp-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Arg-Arg + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Leu-Glu + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Leu-Val-Tyr + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
MATalpha2 repressor + H2O
?
show the reaction diagram
-
-
-
-
?
methyl-casein + H2O
?
show the reaction diagram
-
-
-
-
?
morpholinoacetyl-homophenylalanyl-methylseryl-thienylalanyl-7-amido-4-carbamoylmethylcoumarin + H2O
morpholinoacetyl-homophenylalanine-methylserine-thienylalanine + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
N-Cbz-Leu-Leu-Glu-beta-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-methoxysuccinyl-Glu-Val-Lys-Met-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
N-succinyl-LLVY + 7-amino-4-methylcoumarin
show the reaction diagram
N-succinyl-LLVY-aminoluciferin + H2O
?
show the reaction diagram
-
-
-
-
?
N-t-Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
N-tert-butyloxycarbonyl-LSTR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
highest activity in kidney
-
?
ovalbumin + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized insulin B chain + H2O
?
show the reaction diagram
-
-
-
-
?
p27(KIP1) + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
PS1/gamma-secretase complex component + H2O
?
show the reaction diagram
S-RNase + H2O
?
show the reaction diagram
-
S-RNase is ubiquitinated and degraded by the 26S proteasome
-
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + Suc-Leu-Leu-Val-Tyr
show the reaction diagram
-
-
-
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
succinyl-AAF-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
succinyl-Ile-Ile-Trp-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
succinyl-Leu-Met-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-LLVY-7-amido-4-methylcoumarin + H2O
succinyl-LLVY + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
succinyl-LLVY-aminoluciferin + H2O
succinyl-LLVY + aminoluciferin
show the reaction diagram
t-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
t-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
tert-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide
?
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-LRR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
65% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
-
?
Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
ubiquitinylated proteins
?
show the reaction diagram
unstable green fluorescence protein + H2O
?
show the reaction diagram
-
artificial substrate for the proteasome. The model proteasomal substrate is stabilized by the carboxyl-terminal half of S5a, S5aC
-
-
?
Z-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O
Z-Leu-Leu-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
Z-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
Z-LLE-2-naphthylamide + H2O
Z-LLE + 2-naphthylamine
show the reaction diagram
-
post-acidic proteasome activity
-
-
?
Z-LLE-4-methyl-7-amido-coumarin + H2O
Z-LLE + 4-methyl-7-amino-coumarin
show the reaction diagram
Z-LLE-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-LRR-aminoluciferin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-nLPnLD-aminoluciferin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-